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KCNE1B potassium voltage-gated channel subfamily E regulatory subunit 1B [ Homo sapiens (human) ]

Gene ID: 102723475, updated on 12-Oct-2019

Summary

Official Symbol
KCNE1Bprovided by HGNC
Official Full Name
potassium voltage-gated channel subfamily E regulatory subunit 1Bprovided by HGNC
Primary source
HGNC:HGNC:52280
See related
Ensembl:ENSG00000276289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in heart (RPKM 2.6), kidney (RPKM 2.3) and 5 other tissues See more

Genomic context

See KCNE1B in Genome Data Viewer
Location:
21p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (7816677..7829632, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379504 Neighboring gene small integral membrane protein 11B Neighboring gene family with sequence similarity 243 member B Neighboring gene uncharacterized LOC105379505 Neighboring gene microRNA 6724-1

Genomic regions, transcripts, and products

Genomic Sequence:
NC_000021.9 Chromosome 21 Reference GRCh38.p13 Primary Assembly

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
membrane repolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane repolarization during ventricular cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ventricular cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily E member 1B
Names
potassium channel, voltage gated subfamily E regulatory beta subunit 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330065.1NP_001316994.1  potassium voltage-gated channel subfamily E member 1B

    Status: VALIDATED

    Source sequence(s)
    CU633980
    Consensus CDS
    CCDS82655.1
    UniProtKB/Swiss-Prot
    A0A087WTH5
    Related
    ENSP00000485125.1, ENST00000623803.1
    Conserved Domains (1) summary
    pfam02060
    Location:5129
    ISK_Channel; Slow voltage-gated potassium channel
  2. NM_001369869.1NP_001356798.1  potassium voltage-gated channel subfamily E member 1B

    Status: VALIDATED

    Source sequence(s)
    CU633980
    Related
    ENSP00000477875.2, ENST00000618699.2
    Conserved Domains (1) summary
    pfam02060
    Location:5129
    ISK_Channel; Slow voltage-gated potassium channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    7816677..7829632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723946.2XP_006724009.1  potassium voltage-gated channel subfamily E member 1B isoform X1

    Conserved Domains (1) summary
    pfam02060
    Location:23147
    ISK_Channel; Slow voltage-gated potassium channel
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