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IGHV1-69D immunoglobulin heavy variable 1-69D [ Homo sapiens (human) ]

Gene ID: 102723169, updated on 13-May-2022

Summary

Official Symbol
IGHV1-69Dprovided by HGNC
Official Full Name
immunoglobulin heavy variable 1-69Dprovided by HGNC
Primary source
HGNC:HGNC:49601
See related
Ensembl:ENSG00000280411 IMGT/GENE-DB:IGHV1-69D; AllianceGenome:HGNC:49601
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See IGHV1-69D in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (106762092..106762530, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (101037386..101037824, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 (PATCHES) NW_004166863.1 (1425259..1425697, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy variable 3-69-1 (pseudogene) Neighboring gene immunoglobulin heavy variable 1-69-2 Neighboring gene immunoglobulin heavy variable 2-70 Neighboring gene immunoglobulin heavy variable 3-71 (pseudogene)

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    117815..118253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    106762092..106762530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1253361..1253799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    101037386..101037824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)