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AKAP8 A-kinase anchoring protein 8 [ Homo sapiens (human) ]

Gene ID: 10270, updated on 17-Jun-2019

Summary

Official Symbol
AKAP8provided by HGNC
Official Full Name
A-kinase anchoring protein 8provided by HGNC
Primary source
HGNC:HGNC:378
See related
Ensembl:ENSG00000105127 MIM:604692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKAP-8; AKAP95; AKAP 95; AKAP-95
Summary
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 13.0), spleen (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See AKAP8 in Genome Data Viewer
Location:
19p13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15353385..15379787, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15464332..15490638, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 3 Neighboring gene bromodomain containing 4 Neighboring gene Sharpr-MPRA regulatory region 9920 Neighboring gene A-kinase anchoring protein 8 like Neighboring gene WIZ zinc finger Neighboring gene microRNA 1470

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human A kinase (PRKA) anchor protein 8 (AKAP8) at amino acid residues 310-311 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586B1222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle G2/M phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome IEA
Inferred from Electronic Annotation
more info
 
female pronucleus IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein 8
Names
A kinase (PRKA) anchor protein 8
A-kinase anchor protein, 95kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046946.1 RefSeqGene

    Range
    5028..31308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005858.4NP_005849.1  A-kinase anchor protein 8

    See identical proteins and their annotated locations for NP_005849.1

    Status: REVIEWED

    Source sequence(s)
    AC093060, AI581319, CA429585, Y11997
    Consensus CDS
    CCDS12329.1
    UniProtKB/Swiss-Prot
    O43823
    Related
    ENSP00000269701.1, ENST00000269701.7
    Conserved Domains (1) summary
    pfam04988
    Location:390550
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15353385..15379787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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