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Ifi206 interferon activated gene 206 [ Mus musculus (house mouse) ]

Gene ID: 102639543, updated on 24-Sep-2025
Official Symbol
Ifi206provided by MGI
Official Full Name
interferon activated gene 206provided by MGI
Primary source
MGI:MGI:3646410
See related
Ensembl:ENSMUSG00000037849 AllianceGenome:MGI:3646410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4955; EG240921; Pyblhin-C
Summary
Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including cellular response to interferon-beta; regulation of gene expression; and regulation of innate immune response. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in spleen adult (RPKM 10.6), thymus adult (RPKM 10.0) and 6 other tissues See more
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See Ifi206 in Genome Data Viewer
Location:
1 H3; 1 80.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173296051..173318884, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173468485..173491318, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03074 Neighboring gene STARR-seq mESC enhancer starr_03075 Neighboring gene cell adhesion molecule 3 Neighboring gene absent in melanoma 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175328755-175329056 Neighboring gene STARR-seq mESC enhancer starr_03076 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon TCT) Neighboring gene STARR-positive B cell enhancer ABC_E2021 Neighboring gene STARR-seq mESC enhancer starr_03077 Neighboring gene STARR-positive B cell enhancer ABC_E1574 Neighboring gene STARR-seq mESC enhancer starr_03078 Neighboring gene STARR-positive B cell enhancer ABC_E5856 Neighboring gene STARR-positive B cell enhancer ABC_E11107 Neighboring gene STARR-seq mESC enhancer starr_03079 Neighboring gene STARR-seq mESC enhancer starr_03080 Neighboring gene STARR-positive B cell enhancer ABC_E10059 Neighboring gene STARR-positive B cell enhancer ABC_E4392 Neighboring gene interferon activated gene 214 Neighboring gene interferon activated gene 213 Neighboring gene STARR-positive B cell enhancer ABC_E11699

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Cloning and characterisation of Ifi206: a new murine HIN-200 family member. Ludlow LE, et al. J Cell Biochem, 2008 Mar 1. PMID 17786933
  2. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
  3. The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. Liu CJ, et al. J Biol Chem, 2005 Jan 28. PMID 15557274
  4. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p206 represents the newest HIN-200 family member discovered. It has distinct pattern of expression however maintains many of the hallmarks of HIN-200 proteins. [Ifi206]
    Title: Cloning and characterisation of Ifi206: a new murine HIN-200 family member.
  2. interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation
    Title: The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
interferon activated gene 206
Names
signaling mucin HKR1-like

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372436.1 → NP_001359365.1  interferon activated gene 206

    Status: VALIDATED

    Source sequence(s)
    AC084073
    Consensus CDS
    CCDS87925.1
    UniProtKB/TrEMBL
    G3UZV2
    Conserved Domains (4) summary
    cd08305
    Location:10 → 80
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:214 → 670
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:704 → 870
    HIN; HIN-200/IF120x domain
    pfam15265
    Location:131 → 285
    FAM196; FAM196 family

  2. NM_001372437.1 → NP_001359366.1  interferon activated gene 206

    Status: VALIDATED

    Source sequence(s)
    AC084073
    Consensus CDS
    CCDS87925.1
    UniProtKB/TrEMBL
    G3UZV2
    Related
    ENSMUSP00000134646.3, ENSMUST00000160565.4
    Conserved Domains (4) summary
    cd08305
    Location:10 → 80
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:214 → 670
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:704 → 870
    HIN; HIN-200/IF120x domain
    pfam15265
    Location:131 → 285
    FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173296051..173318884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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