Strit1 small transmembrane regulator of ion transport 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Strit1provided by MGI
Official Full Name: small transmembrane regulator of ion transport 1provided by MGI
Primary source: MGI:MGI:5593461
See related: Ensembl:ENSMUSG00000103476 AllianceGenome:MGI:5593461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DWORF; Gm34302
Summary: Enables enzyme activator activity. Involved in positive regulation of calcium ion transport and regulation of striated muscle contraction. Acts upstream of or within positive regulation of calcium ion import. Located in sarcoplasmic reticulum membrane. Orthologous to human STRIT1 (small transmembrane regulator of ion transport 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward heart adult (RPKM 2.1) See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (63388516..63391327, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (63481095..63483906, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here the show that DWORF has a higher apparent binding affinity for SERCA than PLN and that DWORF overexpression mitigates the contractile dysfunction associated with PLN overexpression, substantiating its role as a potent activator of SERCA.
Title: The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Homology

Orthologs from Annotation Pipeline: 231 organisms have orthologs with human gene Strit1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of ATPase-coupled calcium transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion import into sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion import into sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of slow-twitch skeletal muscle fiber contraction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

Names: SERCA regulator DWORF; Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369305.1 → NP_001356234.1 sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC121840
NM_001369306.1 → NP_001356235.1 sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF isoform 2

Status: VALIDATED

Source sequence(s)

AC121840

Consensus CDS

CCDS89629.1

UniProtKB/Swiss-Prot

P0DN83

Related

ENSMUSP00000147363.2, ENSMUST00000192926.2

Conserved Domains (1) summary

cd20247
Location:1 → 34

DWORF; DWarf Open Reading Frame (DWORF)