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Ttc39aos1 Ttc39a opposite strand RNA 1 [ Mus musculus (house mouse) ]

Gene ID: 102635290, updated on 13-Sep-2022

Summary

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Official Symbol
Ttc39aos1provided by MGI
Official Full Name
Ttc39a opposite strand RNA 1provided by MGI
Primary source
MGI:MGI:3651956
See related
Ensembl:ENSMUSG00000085873 AllianceGenome:MGI:3651956
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm12750; lincRNA-EPS
Summary
Enables chromatin binding activity; ribonucleoprotein complex binding activity; and transcription cis-regulatory region binding activity. Acts upstream of or within with a negative effect on inflammatory response and transcription by RNA polymerase II. Acts upstream of or within gene expression; nucleosome organization; and response to lipopolysaccharide. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 35.8), liver E14 (RPKM 27.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Ttc39aos1 in Genome Data Viewer
Location:
4 C7; 4 51.29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109259476..109263454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109402279..109406257, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene predicted gene, 52702 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene ring finger protein 11 Neighboring gene RIKEN cDNA 4930522H14 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LincRNA-EPS impairs host antiviral immunity by antagonizing viral RNA-PKR interaction. Zhu J, et al. EMBO Rep, 2022 May 4. PMID 35312140, Free PMC Article
  2. LincRNA-EPS alleviates severe acute pancreatitis by suppressing HMGB1-triggered inflammation in pancreatic macrophages. Chen S, et al. Immunology, 2021 Jun. PMID 33512718, Free PMC Article
  3. Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection. Agliano F, et al. Front Cell Infect Microbiol, 2019. PMID 32039056, Free PMC Article
  4. Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation. Hu W, et al. Genes Dev, 2011 Dec 15. PMID 22155924, Free PMC Article
  5. Down-regulation of lincRNA-EPS regulates apoptosis and autophagy in BCG-infected RAW264.7 macrophages via JNK/MAPK signaling pathway. Ke Z, et al. Infect Genet Evol, 2020 Jan. PMID 31669366

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
    Title: Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
  2. Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
    Title: Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
  3. Knockdown of lincRNA-EPS inhibited apoptosis and promoted autophagy in BCG-infected RAW264.7 macrophages.
    Title: Down-regulation of lincRNA-EPS regulates apoptosis and autophagy in BCG-infected RAW264.7 macrophages via JNK/MAPK signaling pathway.
  4. Detailed molecular and genetic approaches demonstrate that the precise regulation of lincRNA-EPS expression in macrophages is essential to control inflammatory responses by suppressing the transcription of key immune genes.
    Title: A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
Submit: New GeneRIF Correction

General gene information

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Homology

Other Names

  • lincRNA erythroid prosurvival

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_negative_effect inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleosome organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_negative_effect transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_131195.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BB079355, KC190025
    Related
    ENSMUST00000247239.1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109259476..109263454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases