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CNKSR1 connector enhancer of kinase suppressor of Ras 1 [ Homo sapiens (human) ]

Gene ID: 10256, updated on 23-Nov-2021

Summary

Official Symbol
CNKSR1provided by HGNC
Official Full Name
connector enhancer of kinase suppressor of Ras 1provided by HGNC
Primary source
HGNC:HGNC:19700
See related
Ensembl:ENSG00000142675 MIM:603272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNK; CNK1
Summary
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Broad expression in skin (RPKM 7.6), thyroid (RPKM 6.2) and 20 other tissues See more
Orthologs
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Genomic context

See CNKSR1 in Genome Data Viewer
Location:
1p36.11
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26177491..26189884)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26503982..26516375)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 230 Neighboring gene ZNF593 opposite strand Neighboring gene zinc finger protein 593 Neighboring gene cation channel sperm associated 4 Neighboring gene ADP ribosylation factor like GTPase 16 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: IPCEF1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
connector enhancer of kinase suppressor of ras 1
Names
CNK homolog protein 1
connector enhancer of KSR 1
connector enhancer of KSR-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047117.1 RefSeqGene

    Range
    5002..17395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297647.2NP_001284576.1  connector enhancer of kinase suppressor of ras 1 isoform 2

    See identical proteins and their annotated locations for NP_001284576.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AK296814, BC011604
    Consensus CDS
    CCDS72732.1
    UniProtKB/Swiss-Prot
    Q969H4
    UniProtKB/TrEMBL
    B4DL25
    Related
    ENSP00000363371.5, ENST00000374253.9
    Conserved Domains (3) summary
    cd09511
    Location:470
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    cd01260
    Location:392505
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam10534
    Location:78162
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
  2. NM_001297648.2NP_001284577.1  connector enhancer of kinase suppressor of ras 1 isoform 3

    See identical proteins and their annotated locations for NP_001284577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF100153, AK001900, AK296814, BC011604
    Consensus CDS
    CCDS76124.1
    UniProtKB/Swiss-Prot
    Q969H4
    UniProtKB/TrEMBL
    B4DL25, G3V160
    Related
    ENSP00000431817.1, ENST00000531191.5
    Conserved Domains (2) summary
    cd01260
    Location:127240
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:141237
    PH; PH domain
  3. NM_006314.3NP_006305.2  connector enhancer of kinase suppressor of ras 1 isoform 1

    See identical proteins and their annotated locations for NP_006305.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF100153, BC011604, DA445069
    Consensus CDS
    CCDS276.1
    UniProtKB/Swiss-Prot
    Q969H4
    UniProtKB/TrEMBL
    Q53GM7
    Related
    ENSP00000354609.6, ENST00000361530.11
    Conserved Domains (6) summary
    cd09511
    Location:470
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:469
    SAM; Sterile alpha motif
    cd00136
    Location:206275
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd01260
    Location:385498
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:399495
    PH; PH domain
    pfam10534
    Location:78162
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26177491..26189884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_023345.1: Suppressed sequence

    Description
    NR_023345.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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