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Hacd2 3-hydroxyacyl-CoA dehydratase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 102551408, updated on 13-Apr-2024

Summary

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Symbol
Hacd2provided by RGD
Full Name
3-hydroxyacyl-CoA dehydratase 2provided by RGD
Primary source
RGD:1306337
See related
Ensembl:ENSRNOG00000038761 AllianceGenome:RGD:1306337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptplb
Summary
Predicted to enable 3-hydroxyacyl-CoA dehydratase activity; 3R-hydroxyacyl-CoA dehydratase activity; and enzyme binding activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 45.3), Heart (RPKM 34.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hacd2 in Genome Data Viewer
Location:
11q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (79175470..79268975, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65667671..65762903, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68985497..68990023, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551038 Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC134481009 Neighboring gene uncharacterized LOC134481011 Neighboring gene myosin light chain kinase Neighboring gene uncharacterized LOC120095664

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B. Wang B, et al. Mol Cell Biol, 2004 Apr. PMID 15024066, Free PMC Article
  2. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. Ikeda M, et al. FEBS Lett, 2008 Jul 9. PMID 18554506
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyacyl-CoA dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
Names
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
protein-tyrosine phosphatase-like member B
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2-like
very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2-like
NP_001389032.1
XP_006248501.2
XP_038944843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402103.1 → NP_001389032.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

RNA

  1. NR_175003.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    Related
    ENSRNOT00000003013.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    79175470..79268975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248439.5 → XP_006248501.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

    Conserved Domains (1) summary
    pfam04387
    Location:85 → 167
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

  2. XM_039088915.2 → XP_038944843.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X2

    Conserved Domains (1) summary
    cl02156
    Location:37 → 141
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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