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Xrcc3 X-ray repair cross complementing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 102551085, updated on 10-Oct-2019

Summary

Official Symbol
Xrcc3provided by RGD
Official Full Name
X-ray repair cross complementing 3provided by RGD
Primary source
RGD:1306849
See related
Ensembl:ENSRNOG00000012141
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 33.8), Thymus (RPKM 31.6) and 9 other tissues See more
Orthologs

Genomic context

See Xrcc3 in Genome Data Viewer
Location:
6q32
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136366917..136380751, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (145372463..145388673, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 5-like 1 Neighboring gene uncharacterized LOC108351304 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene kinesin light chain 1 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene hypothetical protein LOC100363116

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to crossover junction endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to crossover junction endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
DNA repair ISO
Inferred from Sequence Orthology
more info
PubMed 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
PubMed 
double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
 
interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
PubMed 
resolution of mitotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
resolution of mitotic recombination intermediates ISO
Inferred from Sequence Orthology
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
t-circle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
t-circle formation ISO
Inferred from Sequence Orthology
more info
PubMed 
telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
PubMed 
telomere maintenance via telomere trimming ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Rad51C-XRCC3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rad51C-XRCC3 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
replication fork IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
DNA repair protein XRCC3
Names
X-ray repair complementing defective repair in Chinese hamster cells 3
rCG27697-like

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    136366917..136380751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240650.3XP_006240712.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for XP_006240712.1

    Related
    ENSRNOP00000016208.3, ENSRNOT00000016208.3
    Conserved Domains (2) summary
    cd01123
    Location:82337
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:64336
    Rad51; Rad51
  2. XM_008764982.1XP_008763204.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for XP_008763204.1

    Conserved Domains (2) summary
    cd01123
    Location:82337
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:64336
    Rad51; Rad51
  3. XM_006240649.2XP_006240711.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for XP_006240711.1

    Conserved Domains (2) summary
    cd01123
    Location:82337
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:64336
    Rad51; Rad51

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    128413783..128427617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008776325.2XP_008774547.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for XP_008774547.1

    Conserved Domains (2) summary
    cd01123
    Location:82337
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:64336
    Rad51; Rad51
  2. XM_008776326.1XP_008774548.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for XP_008774548.1

    Conserved Domains (2) summary
    cd01123
    Location:82337
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:64336
    Rad51; Rad51
  3. XM_008776324.1XP_008774546.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for XP_008774546.1

    Conserved Domains (2) summary
    cd01123
    Location:82337
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:64336
    Rad51; Rad51
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