Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmtm7provided by MGI
Official Full Name: CKLF-like MARVEL transmembrane domain containing 7provided by MGI
Primary source: MGI:MGI:2447166
See related: Ensembl:ENSMUSG00000032436 AllianceGenome:MGI:2447166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LNV; Cklfsf7
Summary: Predicted to enable cytokine activity. Acts upstream of or within B-1a B cell differentiation. Predicted to be located in extracellular space. Predicted to be active in membrane. Is expressed in thymus primordium. Orthologous to human CMTM7 (CKLF like MARVEL transmembrane domain containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in thymus adult (RPKM 190.5), stomach adult (RPKM 118.3) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 65.13 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (114585904..114611061, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (114756836..114781993, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igmu repertoire of splenic B-1a cells.
Title: Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.
CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
Title: CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
The Cmtm7 deficiency resulted in a slow proliferation and high cell death rate of TrB-1a cells. Thus, Cmtm7 controls B-1a cell development at the transitional stage.
Title: Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage.
The reduction of B-1a cells in Cmtm7(flox/) mice was associated with reduced BCR expression.
Title: A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.
CMTM7 functions to link sIgM and BLNK in the plasma membrane.
Title: Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI481279 (e-PCR)
- UniSTS:164424

D9Mit81 (e-PCR), detects polymorphism
- UniSTS:131968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B-1a B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasma cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 7

Names: chemokine-like factor super family 7; chemokine-like factor superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252479.1 → NP_001239408.1 CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 2

See identical proteins and their annotated locations for NP_001239408.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA002761, AC163344, BC038633

Consensus CDS

CCDS57709.1

UniProtKB/TrEMBL

Q3THH0

Related

ENSMUSP00000081927.8, ENSMUST00000084867.9

Conserved Domains (1) summary

cl04571
Location:32 → 119

MARVEL; Membrane-associating domain
NM_133978.2 → NP_598739.1 CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_598739.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC163344, AF188504

Consensus CDS

CCDS57710.1

UniProtKB/Swiss-Prot

Q8CHW2, Q9ESD6

UniProtKB/TrEMBL

Q3THH0

Related

ENSMUSP00000035009.9, ENSMUST00000035009.16

Conserved Domains (1) summary

pfam01284
Location:32 → 152

MARVEL; Membrane-associating domain