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KIT KIT proto-oncogene, receptor tyrosine kinase [ Vicugna pacos (alpaca) ]

Gene ID: 102528563, updated on 8-Apr-2026
Gene symbol
KIT
Gene description
KIT proto-oncogene, receptor tyrosine kinase
Gene type
protein coding
RefSeq status
MODEL
Organism
Vicugna pacos
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Vicugna
Orthologs
all
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Try the new Transcripts and proteins table
See KIT in Genome Data Viewer
Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_04 current VicPac4 (GCF_048564905.1) 2 NC_132988.1 (84234335..84311923, complement)
102 previous assembly VicPac3.1 (GCF_000164845.3) 2 Unlocalized Scaffold NW_021964157.1 (38135270..38212578)

Chromosome 2 - NC_132988.1Genomic Context describing neighboring genes Neighboring gene mitochondrial-processing peptidase subunit beta pseudogene Neighboring gene ATP synthase subunit ATP5MJ, mitochondrial Neighboring gene uncharacterized LOC140700290 Neighboring gene uncharacterized LOC140700287

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Whole-genome sequencing of alpaca revealed variants in KIT gene potentially associated with the white coat phenotype. Pallotti S, et al. Anim Genet, 2023 Dec. PMID 37778745
  2. A non-synonymous SNP in exon 3 of the KIT gene is responsible for the classic grey phenotype in alpacas (Vicugna pacos). Jones M, et al. Anim Genet, 2019 Oct. PMID 31297861
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whole-genome sequencing of alpaca revealed variants in KIT gene potentially associated with the white coat phenotype.
    Title: Whole-genome sequencing of alpaca revealed variants in KIT gene potentially associated with the white coat phenotype.
  2. The classic grey phenotype in alpacas is the result of a c.376G>A (p.Gly126Arg) SNP in exon 3 of KIT. These data also support the hypothesis that the grey phenotype is autosomal dominant and that the mutation is most likely homozygous lethal.
    Title: A non-synonymous SNP in exon 3 of the KIT gene is responsible for the classic grey phenotype in alpacas (Vicugna pacos).
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of signaling receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
mast/stem cell growth factor receptor Kit
Names
mast/stem cell growth factor receptor

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_048564905.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference VicPac4

Genomic

  1. NC_132988.1 Reference VicPac4

    Range
    84234335..84311923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_072943734.1 → XP_072799835.1  mast/stem cell growth factor receptor Kit isoform X6

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0ABM5BTV3

  2. XM_031688017.2 → XP_031543877.1  mast/stem cell growth factor receptor Kit isoform X8

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0A6J3BF61
    Conserved Domains (5) summary
    smart00409
    Location:44 → 111
    IG; Immunoglobulin
    cd05104
    Location:549 → 923
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain

  3. XM_006198138.4 → XP_006198200.1  mast/stem cell growth factor receptor Kit isoform X4

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0A6I9HZ85
    Conserved Domains (5) summary
    smart00409
    Location:44 → 111
    IG; Immunoglobulin
    cd05104
    Location:553 → 928
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain

  4. XM_006198139.3 → XP_006198201.1  mast/stem cell growth factor receptor Kit isoform X7

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0A6I9HZW9
    Conserved Domains (5) summary
    smart00409
    Location:44 → 111
    IG; Immunoglobulin
    cd05104
    Location:549 → 924
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain

  5. XM_072943756.1 → XP_072799857.1  mast/stem cell growth factor receptor Kit isoform X9

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0ABM5BTX4

  6. XM_072943727.1 → XP_072799828.1  mast/stem cell growth factor receptor Kit isoform X5

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0ABM5BTU3

  7. XM_031688006.2 → XP_031543866.1  mast/stem cell growth factor receptor Kit isoform X3

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0A6J3BH17
    Conserved Domains (5) summary
    smart00409
    Location:49 → 116
    IG; Immunoglobulin
    cd05104
    Location:554 → 929
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    cd00096
    Location:431 → 510
    Ig; Immunoglobulin domain
    cd05860
    Location:316 → 416
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    pfam00047
    Location:221 → 310
    ig; Immunoglobulin domain

  8. XM_031688002.2 → XP_031543862.1  mast/stem cell growth factor receptor Kit isoform X2

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0A6J3BF46
    Conserved Domains (5) summary
    smart00409
    Location:49 → 116
    IG; Immunoglobulin
    cd05104
    Location:558 → 932
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    cd00096
    Location:431 → 510
    Ig; Immunoglobulin domain
    cd05860
    Location:316 → 416
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    pfam00047
    Location:221 → 310
    ig; Immunoglobulin domain

  9. XM_031688000.2 → XP_031543860.1  mast/stem cell growth factor receptor Kit isoform X1

    UniProtKB/TrEMBL
    A0A646RQK0, A0A646RQK6, A0A646RR05, A0A6J3B9U7
    Conserved Domains (5) summary
    smart00409
    Location:49 → 116
    IG; Immunoglobulin
    cd05104
    Location:558 → 933
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    cd00096
    Location:431 → 510
    Ig; Immunoglobulin domain
    cd05860
    Location:316 → 416
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    pfam00047
    Location:221 → 310
    ig; Immunoglobulin domain
Nucleotide Protein
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