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SRRM1 serine and arginine repetitive matrix 1 [ Homo sapiens (human) ]

Gene ID: 10250, updated on 4-Oct-2020

Summary

Official Symbol
SRRM1provided by HGNC
Official Full Name
serine and arginine repetitive matrix 1provided by HGNC
Primary source
HGNC:HGNC:16638
See related
Ensembl:ENSG00000133226 MIM:605975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
160-KD; POP101; SRM160
Expression
Ubiquitous expression in ovary (RPKM 22.6), prostate (RPKM 22.3) and 25 other tissues See more
Orthologs

Genomic context

See SRRM1 in Genome Data Viewer
Location:
1p36.11
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (24643273..24673281)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24969594..24999772)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript Neighboring gene ribosomal protein L26 pseudogene 8 Neighboring gene non-compact myelin associated protein Neighboring gene Sharpr-MPRA regulatory region 6401 Neighboring gene chloride intracellular channel 4 Neighboring gene RNA, U6 small nuclear 1208, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human serine/arginine repetitive matrix 1 (SRRM1) at amino acid residues 123-124 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39488

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
RNA splicing, via transesterification reactions TAS
Traceable Author Statement
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/arginine repetitive matrix protein 1
Names
SR-related nuclear matrix protein of 160 kDa
Ser/Arg-related nuclear matrix protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303448.2NP_001290377.1  serine/arginine repetitive matrix protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001290377.1

    Status: VALIDATED

    Source sequence(s)
    AA744578, AF419855, AK302498, AW958761, BG178896, CX782666
    UniProtKB/Swiss-Prot
    Q8IYB3
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    pfam15087
    Location:612741
    DUF4551; Protein of unknown function (DUF4551)
  2. NM_001303449.1NP_001290378.1  serine/arginine repetitive matrix protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001290378.1

    Status: VALIDATED

    Source sequence(s)
    AA744578, AF419855, AK302498, AK307419, AW958761, BG178896, CX782666, DC353932
    UniProtKB/Swiss-Prot
    Q8IYB3
    UniProtKB/TrEMBL
    B7Z7U0
    Conserved Domains (2) summary
    pfam01480
    Location:776
    PWI; PWI domain
    pfam15087
    Location:573702
    DUF4551; Protein of unknown function (DUF4551)
  3. NM_001366565.1NP_001353494.1  serine/arginine repetitive matrix protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:523657
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  4. NM_001366566.1NP_001353495.1  serine/arginine repetitive matrix protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:523657
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  5. NM_001366567.1NP_001353496.1  serine/arginine repetitive matrix protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:521655
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  6. NM_001366568.1NP_001353497.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    PHA03307
    Location:537671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  7. NM_001366569.1NP_001353498.1  serine/arginine repetitive matrix protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl26464
    Location:414743
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:619753
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  8. NM_001366570.1NP_001353499.1  serine/arginine repetitive matrix protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    PHA03247
    Location:298658
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  9. NM_001366571.1NP_001353500.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    PHA03307
    Location:537671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  10. NM_001366572.1NP_001353501.1  serine/arginine repetitive matrix protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:522656
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  11. NM_001366573.1NP_001353502.1  serine/arginine repetitive matrix protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:535669
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  12. NM_001366575.1NP_001353504.1  serine/arginine repetitive matrix protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl26464
    Location:381741
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:617751
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  13. NM_001366576.1NP_001353505.1  serine/arginine repetitive matrix protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (4) summary
    PHA03247
    Location:384713
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:589723
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:121209
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:46115
    PWI; PWI domain
  14. NM_001366577.1NP_001353506.1  serine/arginine repetitive matrix protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl25701
    Location:121209
    RuvB_N; Holliday junction DNA helicase ruvB N-terminus
    cl28033
    Location:590724
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  15. NM_001366578.1NP_001353507.1  serine/arginine repetitive matrix protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    PHA03247
    Location:301630
    PHA03247; large tegument protein UL36; Provisional
    PRK04195
    Location:38126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  16. NM_001366581.1NP_001353510.1  serine/arginine repetitive matrix protein 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    PHA03307
    Location:588722
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK04195
    Location:121209
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:46115
    PWI; PWI domain
  17. NM_001366582.1NP_001353511.1  serine/arginine repetitive matrix protein 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl28033
    Location:605739
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  18. NM_001366584.1NP_001353513.1  serine/arginine repetitive matrix protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:521655
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  19. NM_001366585.1NP_001353514.1  serine/arginine repetitive matrix protein 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    PHA03247
    Location:331660
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  20. NM_001366586.1NP_001353515.1  serine/arginine repetitive matrix protein 1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl25701
    Location:38126
    RuvB_N; Holliday junction DNA helicase ruvB N-terminus
    cl28033
    Location:493627
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  21. NM_001366587.1NP_001353516.1  serine/arginine repetitive matrix protein 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl25701
    Location:38126
    RuvB_N; Holliday junction DNA helicase ruvB N-terminus
    cl28033
    Location:507641
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  22. NM_001366588.1NP_001353517.1  serine/arginine repetitive matrix protein 1 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl28033
    Location:604738
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  23. NM_001366589.1NP_001353518.1  serine/arginine repetitive matrix protein 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl28033
    Location:603737
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  24. NM_001366590.1NP_001353519.1  serine/arginine repetitive matrix protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:535669
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  25. NM_001366591.1NP_001353520.1  serine/arginine repetitive matrix protein 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl25701
    Location:38126
    RuvB_N; Holliday junction DNA helicase ruvB N-terminus
    cl28033
    Location:507641
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  26. NM_001366592.1NP_001353521.1  serine/arginine repetitive matrix protein 1 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl26464
    Location:350709
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:574708
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  27. NM_001366593.1NP_001353522.1  serine/arginine repetitive matrix protein 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    PHA03247
    Location:331660
    PHA03247; large tegument protein UL36; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  28. NM_001366594.1NP_001353523.1  serine/arginine repetitive matrix protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (3) summary
    PHA03247
    Location:301630
    PHA03247; large tegument protein UL36; Provisional
    PRK04195
    Location:38126
    PRK04195; replication factor C large subunit; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  29. NM_001366595.1NP_001353524.1  serine/arginine repetitive matrix protein 1 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686, KU178513
    Related
    ENSP00000363510.3, ENST00000374389.8
    Conserved Domains (2) summary
    pfam01480
    Location:46115
    PWI; PWI domain
    cl28033
    Location:620754
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  30. NM_001366596.1NP_001353525.1  serine/arginine repetitive matrix protein 1 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:776
    PWI; PWI domain
    cl28033
    Location:551685
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  31. NM_001366597.1NP_001353526.1  serine/arginine repetitive matrix protein 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:776
    PWI; PWI domain
    cl28033
    Location:581715
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  32. NM_001366598.1NP_001353527.1  serine/arginine repetitive matrix protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:522656
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  33. NM_001366599.1NP_001353528.1  serine/arginine repetitive matrix protein 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl28033
    Location:521655
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  34. NM_001366600.1NP_001353529.1  serine/arginine repetitive matrix protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
    Conserved Domains (2) summary
    PHA03307
    Location:537671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  35. NM_005839.4NP_005830.2  serine/arginine repetitive matrix protein 1 isoform 2

    See identical proteins and their annotated locations for NP_005830.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF048977, BC017315, BC036187, CX782666
    Consensus CDS
    CCDS255.1
    UniProtKB/Swiss-Prot
    Q8IYB3
    UniProtKB/TrEMBL
    A0A0S2Z4W1
    Related
    ENSP00000326261.8, ENST00000323848.14
    Conserved Domains (2) summary
    PHA03307
    Location:606740
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:46115
    PWI; PWI domain

RNA

  1. NR_159378.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  2. NR_159379.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  3. NR_159380.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  4. NR_159382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  5. NR_159383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  6. NR_159384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  7. NR_159385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  8. NR_159386.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  9. NR_159387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  10. NR_159388.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  11. NR_159389.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  12. NR_159390.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686
  13. NR_159391.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445648, AL445686

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    24643273..24673281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449353.1XP_024305121.1  serine/arginine repetitive matrix protein 1 isoform X29

    Conserved Domains (3) summary
    pfam01480
    Location:132
    PWI; PWI domain
    cl25701
    Location:38126
    RuvB_N; Holliday junction DNA helicase ruvB N-terminus
    cl26464
    Location:268628
    Atrophin-1; Atrophin-1 family
  2. XM_017000032.2XP_016855521.1  serine/arginine repetitive matrix protein 1 isoform X28

  3. XM_011540480.2XP_011538782.1  serine/arginine repetitive matrix protein 1 isoform X19

    See identical proteins and their annotated locations for XP_011538782.1

    Conserved Domains (2) summary
    PHA03307
    Location:537671
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01480
    Location:132
    PWI; PWI domain
  4. XM_017000013.1XP_016855502.1  serine/arginine repetitive matrix protein 1 isoform X4

  5. XM_017000011.1XP_016855500.1  serine/arginine repetitive matrix protein 1 isoform X2

  6. XM_017000014.1XP_016855503.1  serine/arginine repetitive matrix protein 1 isoform X5

  7. XM_017000015.1XP_016855504.1  serine/arginine repetitive matrix protein 1 isoform X6

  8. XM_017000012.1XP_016855501.1  serine/arginine repetitive matrix protein 1 isoform X3

  9. XM_017000017.1XP_016855506.1  serine/arginine repetitive matrix protein 1 isoform X8

  10. XM_017000034.1XP_016855523.1  serine/arginine repetitive matrix protein 1 isoform X31

RNA

  1. XR_001736902.1 RNA Sequence

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