POP7 POP7 homolog, ribonuclease P/MRP subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: POP7provided by HGNC
Official Full Name: POP7 homolog, ribonuclease P/MRP subunitprovided by HGNC
Primary source: HGNC:HGNC:19949
See related: Ensembl:ENSG00000172336 HPRD:09357; MIM:606113; Vega:OTTHUMG00000044311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RPP2; RPP20; 0610037N12Rik
Orthologs: mouse all

Genomic context

See POP7 in Genome Data Viewer Map Viewer

Location:: 7q22.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
108	current	GRCh38.p7 (GCF_000001405.33)	7	NC_000007.14 (100706053..100707500)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (100303676..100305123)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

analyses of interactions with deletion mutant proteins indicate that the Alba-type core domain of both Rpp20 and Rpp25 contains most of the determinants for mutual association and P3 RNA recognition.
Title: Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
RNA transport, organism-specific biosystem (from KEGG)
RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
RNA transport, conserved biosystem (from KEGG)
RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
tRNA processing, organism-specific biosystem (from REACTOME)
tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48437 (e-PCR)
- UniSTS:11983

STS-T99819 (e-PCR)
- UniSTS:7382

Homology

Homologs of the POP7 gene: The POP7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and fruit fly.
Orthologs from Annotation Pipeline: 133 organisms have orthologs with human gene POP7
Map Viewer (Mouse, Rat)
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
poly(A) RNA binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ribonuclease P activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic	IEA Inferred from Electronic Annotation more info
tRNA 5'-leader removal	TAS Traceable Author Statement more info
tRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleolar ribonuclease P complex	TAS Traceable Author Statement more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ribonuclease P protein subunit p20

Names: POP7 (processing of precursor, S. cerevisiae) homolog; RNaseP protein p20; hPOP7; processing of precursor 7, ribonuclease P subunit; processing of precursor 7, ribonuclease P/MRP subunit; ribonucleases P/MRP protein subunit POP7 homolog

NP_005828.2

EC 3.1.26.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.