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POP7 POP7 homolog, ribonuclease P/MRP subunit [ Homo sapiens (human) ]

Gene ID: 10248, updated on 21-Dec-2019

Summary

Official Symbol
POP7provided by HGNC
Official Full Name
POP7 homolog, ribonuclease P/MRP subunitprovided by HGNC
Primary source
HGNC:HGNC:19949
See related
Ensembl:ENSG00000172336 MIM:606113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPP2; RPP20; 0610037N12Rik
Expression
Ubiquitous expression in prostate (RPKM 11.3), brain (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See POP7 in Genome Data Viewer
Location:
7q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100706121..100707486)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100303676..100305123)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 2 Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3567 Neighboring gene erythropoietin Neighboring gene zonadhesin (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
tRNA 5'-leader removal TAS
Traceable Author Statement
more info
 
tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p20
Names
POP7 (processing of precursor, S. cerevisiae) homolog
RNaseP protein p20
hPOP7
processing of precursor 7, ribonuclease P subunit
processing of precursor 7, ribonuclease P/MRP subunit
ribonucleases P/MRP protein subunit POP7 homolog
NP_005828.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005837.3NP_005828.2  ribonuclease P protein subunit p20

    See identical proteins and their annotated locations for NP_005828.2

    Status: VALIDATED

    Source sequence(s)
    BC001430, BI666854
    Consensus CDS
    CCDS5704.1
    UniProtKB/Swiss-Prot
    O75817
    Related
    ENSP00000304353.4, ENST00000303151.5
    Conserved Domains (1) summary
    pfam12328
    Location:33133
    Rpp20; Rpp20 subunit of nuclear RNase MRP and P

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100706121..100707486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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