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RIDA reactive intermediate imine deaminase A homolog [ Homo sapiens (human) ]

Gene ID: 10247, updated on 8-Jul-2021

Summary

Official Symbol
RIDAprovided by HGNC
Official Full Name
reactive intermediate imine deaminase A homologprovided by HGNC
Primary source
HGNC:HGNC:16897
See related
Ensembl:ENSG00000132541 MIM:602487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP; P14.5; UK114; HRSP12; hp14.5
Expression
Biased expression in liver (RPKM 363.6), kidney (RPKM 202.2) and 3 other tissues See more
Orthologs
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Genomic context

See RIDA in Genome Data Viewer
Location:
8q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (98102344..98117171, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99114572..99129399, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 703, pseudogene Neighboring gene glutamate rich 5 Neighboring gene tRNA-undetermined (NNN) 2-1 Neighboring gene POP1 homolog, ribonuclease P/MRP subunit Neighboring gene uncharacterized LOC105375660 Neighboring gene RNA, U6 small nuclear 914, pseudogene Neighboring gene NIPA like domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-iminobutanoate deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 2-iminopropanoate deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deaminase activity TAS
Traceable Author Statement
more info
 
enables endoribonuclease activity, producing 3'-phosphomonoesters ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
 
involved_in L-threonine catabolic process to glycine TAS
Traceable Author Statement
more info
 
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organonitrogen compound catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organonitrogen compound catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to salt IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
2-iminobutanoate/2-iminopropanoate deaminase
Names
14.5 kDa translational inhibitor protein
UK114 antigen homolog
heat-responsive protein 12
perchloric acid-soluble protein
ribonuclease UK114
translation inhibitor L-PSP ribonuclease
translational inhibitor p14.5
translational inhibitor protein p14.5
NP_005827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005836.3NP_005827.1  2-iminobutanoate/2-iminopropanoate deaminase

    See identical proteins and their annotated locations for NP_005827.1

    Status: VALIDATED

    Source sequence(s)
    BC012592, X95384
    Consensus CDS
    CCDS6276.1
    UniProtKB/Swiss-Prot
    P52758
    UniProtKB/TrEMBL
    A0A024R9H2
    Related
    ENSP00000254878.3, ENST00000254878.8
    Conserved Domains (1) summary
    TIGR00004
    Location:6129
    TIGR00004; reactive intermediate/imine deaminase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    98102344..98117171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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