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ITCH itchy E3 ubiquitin protein ligase [ Myotis lucifugus (little brown bat) ]

Gene ID: 102427630, updated on 23-Oct-2020

Summary

Gene symbol
ITCH
Gene description
itchy E3 ubiquitin protein ligase
See related
Ensembl:ENSMLUG00000004798
Gene type
protein coding
RefSeq status
MODEL
Organism
Myotis lucifugus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae; Myotis
Orthologs
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Genomic context

See ITCH in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
102 current Myoluc2.0 (GCF_000147115.1) Unplaced Scaffold NW_005871108.1 (4289216..4407348)

NW_005871108.1Genomic Context describing neighboring genes Neighboring gene tubulin alpha-1C chain-like Neighboring gene agouti signaling protein Neighboring gene adenosylhomocysteinase Neighboring gene dynein light chain roadblock-type 1 Neighboring gene microtubule associated protein 1 light chain 3 alpha

Genomic regions, transcripts, and products

Genomic Sequence:
NW_005871108 Unplaced Scaffold Reference Myoluc2.0

General protein information

Preferred Names
E3 ubiquitin-protein ligase Itchy homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Myotis lucifugus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Myoluc2.0

Genomic

  1. NW_005871108.1 Reference Myoluc2.0

    Range
    4289216..4407348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006089423.2XP_006089485.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    See identical proteins and their annotated locations for XP_006089485.1

    Conserved Domains (5) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:441472
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:534862
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:510863
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:402431
    WW; WW domain
  2. XM_006089425.2XP_006089487.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    Related
    ENSMLUP00000004382.2, ENSMLUT00000004811.2
    Conserved Domains (5) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:438469
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:531859
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:507860
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:399428
    WW; WW domain
  3. XM_006089424.2XP_006089486.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    See identical proteins and their annotated locations for XP_006089486.1

    Conserved Domains (5) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:441472
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:534862
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:510863
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:402431
    WW; WW domain
  4. XM_023754394.1XP_023610162.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

    Conserved Domains (3) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:321808
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:290319
    WW; WW domain
  5. XM_023754395.1XP_023610163.1  E3 ubiquitin-protein ligase Itchy homolog isoform X4

    Conserved Domains (3) summary
    COG5021
    Location:246790
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:215244
    WW; WW domain
    cl14603
    Location:265
    C2; C2 domain
  6. XM_014456481.2XP_014311967.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (5) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:441472
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:534862
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:510863
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:402431
    WW; WW domain
  7. XM_023754396.1XP_023610164.1  E3 ubiquitin-protein ligase Itchy homolog isoform X5

    Conserved Domains (1) summary
    COG5021
    Location:29492
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
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