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DCAF7 DDB1 and CUL4 associated factor 7 [ Homo sapiens (human) ]

Gene ID: 10238, updated on 12-Jul-2019


Official Symbol
DCAF7provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 7provided by HGNC
Primary source
See related
Ensembl:ENSG00000136485 MIM:605973
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AN11; HAN11; WDR68; SWAN-1
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Ubiquitous expression in kidney (RPKM 18.2), brain (RPKM 17.9) and 25 other tissues See more

Genomic context

See DCAF7 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (63550435..63594279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61627796..61671641)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene angiotensin I converting enzyme 3, pseudogene Neighboring gene potassium voltage-gated channel subfamily H member 6 Neighboring gene RNA, U6 small nuclear 288, pseudogene Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene family with sequence similarity 136 member A pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
    Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
post-translational protein modification TAS
Traceable Author Statement
more info
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
cytoplasm TAS
Traceable Author Statement
more info
cytosol IDA
Inferred from Direct Assay
more info
nuclear body IDA
Inferred from Direct Assay
more info
nuclear matrix IDA
Inferred from Direct Assay
more info
nucleoplasm IDA
Inferred from Direct Assay
more info
nucleoplasm TAS
Traceable Author Statement
more info
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
protein-containing complex IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
DDB1- and CUL4-associated factor 7
WD repeat-containing protein 68
WD repeat-containing protein An11 homolog
human anthocyanin
seven-WD-repeat protein of the AN11 family-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_033092.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005828.5NP_005819.3  DDB1- and CUL4-associated factor 7

    See identical proteins and their annotated locations for NP_005819.3

    Status: REVIEWED

    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC046185, BF507629, HY023965, U94747
    Consensus CDS
    ENSP00000483236.1, ENST00000614556.5
    Conserved Domains (2) summary
    7WD40; WD40 repeat [structural motif]
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...


  1. NR_073585.2 RNA Sequence

    Status: REVIEWED

    Transcript Variant: This variant (2) uses alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC001264, HY023965

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003725.1: Suppressed sequence

    NM_001003725.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
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