U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myzap myocardial zonula adherens protein [ Mus musculus (house mouse) ]

Gene ID: 102371, updated on 12-May-2024

Summary

Official Symbol
Myzapprovided by MGI
Official Full Name
myocardial zonula adherens proteinprovided by MGI
Primary source
MGI:MGI:2142908
See related
Ensembl:ENSMUSG00000041361 AllianceGenome:MGI:2142908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcom1; Gm640; Myozap; Gm20502; Grinl1a7
Summary
Involved in intracellular signal transduction. Located in I band. Is extrinsic component of cytoplasmic side of plasma membrane. Colocalizes with cortical actin cytoskeleton. Is expressed in heart; lung; and vascular system. Orthologous to several human genes including POLR2M (RNA polymerase II subunit M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 66.6), lung adult (RPKM 24.2) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Myzap in Genome Data Viewer
Location:
9 D; 9 39.85 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71411629..71499642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71504347..71592360, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32769 Neighboring gene STARR-seq mESC enhancer starr_24572 Neighboring gene STARR-seq mESC enhancer starr_24574 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide M Neighboring gene STARR-seq mESC enhancer starr_24575 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71418063-71418246 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 pseudogene Neighboring gene dynein light chain 1, cytoplasmic-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of ER location IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in I band IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in I band IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II, holoenzyme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myocardial zonula adherens protein
Names
GRINL1A complex locus protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033208.4NP_001028380.1  myocardial zonula adherens protein precursor

    See identical proteins and their annotated locations for NP_001028380.1

    Status: VALIDATED

    Source sequence(s)
    AC107662, AC160560
    Consensus CDS
    CCDS23327.1
    UniProtKB/Swiss-Prot
    B2RT00, Q3UIJ9
    UniProtKB/TrEMBL
    E9Q565
    Related
    ENSMUSP00000091342.2, ENSMUST00000093823.8
    Conserved Domains (4) summary
    pfam15619
    Location:203381
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cd16269
    Location:277290
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:265358
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl20817
    Location:205310
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    71411629..71499642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)