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LRRC17 leucine rich repeat containing 17 [ Homo sapiens (human) ]

Gene ID: 10234, updated on 22-Aug-2021

Summary

Official Symbol
LRRC17provided by HGNC
Official Full Name
leucine rich repeat containing 17provided by HGNC
Primary source
HGNC:HGNC:16895
See related
Ensembl:ENSG00000128606 MIM:618749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P37NB
Expression
Biased expression in ovary (RPKM 29.2), gall bladder (RPKM 13.5) and 10 other tissues See more
Orthologs
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Genomic context

See LRRC17 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102913000..102945111)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102553447..102585558)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 185 member A Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene RNA, U6 small nuclear 1136, pseudogene Neighboring gene RN7SK pseudogene 198 Neighboring gene Sharpr-MPRA regulatory region 11249 Neighboring gene nuclear factor, erythroid 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in bone marrow development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 17
Names
37 kDa leucine-rich repeat (LRR) protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031692.3NP_001026862.1  leucine-rich repeat-containing protein 17 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC073127, AI961444, BC027903, DA749917
    Consensus CDS
    CCDS34721.1
    UniProtKB/Swiss-Prot
    Q8N6Y2
    Related
    ENSP00000344242.4, ENST00000339431.9
    Conserved Domains (4) summary
    cd00116
    Location:267351
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6381
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:294332
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:272328
    LRR_8; Leucine rich repeat
  2. NM_005824.3NP_005815.2  leucine-rich repeat-containing protein 17 isoform 2 precursor

    See identical proteins and their annotated locations for NP_005815.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' UTR and coding region, compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073127, AI961444, DA749917, U32907
    Consensus CDS
    CCDS5727.1
    UniProtKB/Swiss-Prot
    Q8N6Y2
    Related
    ENSP00000249377.4, ENST00000249377.4
    Conserved Domains (4) summary
    sd00031
    Location:6383
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:217246
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:105146
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:84141
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102913000..102945111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250108.1XP_005250165.1  leucine-rich repeat-containing protein 17 isoform X1

    See identical proteins and their annotated locations for XP_005250165.1

    UniProtKB/Swiss-Prot
    Q8N6Y2
    Conserved Domains (4) summary
    cd00116
    Location:267351
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6381
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:294332
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:272328
    LRR_8; Leucine rich repeat
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