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LRRC23 leucine rich repeat containing 23 [ Homo sapiens (human) ]

Gene ID: 10233, updated on 21-Dec-2019

Summary

Official Symbol
LRRC23provided by HGNC
Official Full Name
leucine rich repeat containing 23provided by HGNC
Primary source
HGNC:HGNC:19138
See related
Ensembl:ENSG00000010626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRPB7
Expression
Broad expression in testis (RPKM 16.2), lung (RPKM 5.4) and 20 other tissues See more
Orthologs

Genomic context

See LRRC23 in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6904822..6914229)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7013897..7023406)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369632 Neighboring gene ribosomal protein L13 pseudogene 5 Neighboring gene DSTN pseudogene 2 Neighboring gene enolase 2 Neighboring gene atrophin 1 Neighboring gene atrophin 1 repeat instability region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 23
Names
leucine-rich protein B7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135217.2NP_001128689.1  leucine-rich repeat-containing protein 23 isoform a

    See identical proteins and their annotated locations for NP_001128689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AI524335, AK292291, AK292367, DB027456
    Consensus CDS
    CCDS8569.1
    UniProtKB/Swiss-Prot
    Q53EV4
    UniProtKB/TrEMBL
    A8K8K2
    Related
    ENSP00000390932.2, ENST00000443597.7
    Conserved Domains (3) summary
    sd00033
    Location:93114
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:200241
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:200255
    LRR_8; Leucine rich repeat
  2. NM_006992.4NP_008923.1  leucine-rich repeat-containing protein 23 isoform b

    See identical proteins and their annotated locations for NP_008923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK292367, BC029858, U72508
    Consensus CDS
    CCDS8568.1
    UniProtKB/Swiss-Prot
    Q53EV4
    UniProtKB/TrEMBL
    A8K8K2
    Related
    ENSP00000317464.5, ENST00000323702.9
    Conserved Domains (3) summary
    sd00033
    Location:93114
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:200241
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:200256
    LRR_8; Leucine rich repeat
  3. NM_201650.3NP_964013.1  leucine-rich repeat-containing protein 23 isoform a

    See identical proteins and their annotated locations for NP_964013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK292367, BC029858
    Consensus CDS
    CCDS8569.1
    UniProtKB/Swiss-Prot
    Q53EV4
    UniProtKB/TrEMBL
    A8K8K2
    Related
    ENSP00000007969.8, ENST00000007969.12
    Conserved Domains (3) summary
    sd00033
    Location:93114
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:200241
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:200255
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6904822..6914229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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