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MSLN mesothelin [ Homo sapiens (human) ]

Gene ID: 10232, updated on 11-Sep-2019

Summary

Official Symbol
MSLNprovided by HGNC
Official Full Name
mesothelinprovided by HGNC
Primary source
HGNC:HGNC:7371
See related
Ensembl:ENSG00000102854 MIM:601051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPF; SMRP
Summary
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Expression
Biased expression in lung (RPKM 16.4), stomach (RPKM 4.7) and 7 other tissues See more
Orthologs

Genomic context

See MSLN in Genome Data Viewer
Location:
16p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (760734..768865)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (810765..818865)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene hydroxyacylglutathione hydrolase like Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene MSLN promoter region Neighboring gene mesothelin like Neighboring gene microRNA 662 Neighboring gene RNA pseudouridine synthase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mesothelin
Names
CAK1 antigen
megakaryocyte potentiating factor
pre-pro-megakaryocyte-potentiating factor
soluble MPF mesothelin related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177355.3NP_001170826.1  mesothelin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001170826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL031258, AY743922, BC003512, BC009272
    Consensus CDS
    CCDS45370.1
    UniProtKB/Swiss-Prot
    Q13421
    Related
    ENSP00000456008.1, ENST00000563941.5
    Conserved Domains (1) summary
    pfam06060
    Location:1608
    Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
  2. NM_005823.6NP_005814.2  mesothelin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005814.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Both variants 1 and 3 encode the same isoform isoform (1).
    Source sequence(s)
    AL031258, AY743922, BC003512
    Consensus CDS
    CCDS45370.1
    UniProtKB/Swiss-Prot
    Q13421
    Related
    ENSP00000442965.2, ENST00000545450.7
    Conserved Domains (1) summary
    pfam06060
    Location:1608
    Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
  3. NM_013404.4NP_037536.2  mesothelin isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_037536.2

    Status: REVIEWED

    Description
    Transcript Variant: This transcript variant (2) uses an alternate splice site in the coding region, compared to variant 1. Variant 2 encodes isoform 2 which is longer than isoform 1.
    Source sequence(s)
    AL545401, BC003512, BC009272, CB266931, D49441
    Consensus CDS
    CCDS32356.1
    UniProtKB/Swiss-Prot
    Q13421
    Related
    ENSP00000372313.3, ENST00000382862.7
    Conserved Domains (1) summary
    pfam06060
    Location:1616
    Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    760734..768865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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