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NBR2 neighbor of BRCA1 lncRNA 2 [ Homo sapiens (human) ]

Gene ID: 10230, updated on 17-Jun-2019

Summary

Official Symbol
NBR2provided by HGNC
Official Full Name
neighbor of BRCA1 lncRNA 2provided by HGNC
Primary source
HGNC:HGNC:20691
See related
Ensembl:ENSG00000198496
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCRNA00192
Summary
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in thyroid (RPKM 6.8), spleen (RPKM 3.3) and 25 other tissues See more

Genomic context

See NBR2 in Genome Data Viewer
Location:
17q21.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43125557..43153671)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41277600..41297130)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BRCA1 DNA repair associated Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene BRCA1 intronic recombination region Neighboring gene BRCA1 intron 2 regulatory region Neighboring gene BRCA1 promoter region Neighboring gene uncharacterized LOC101929767 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 29 Neighboring gene BRCA1P1 intergenic recombination region Neighboring gene BRCA1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Neighbor of BRCA1 gene 2 protein
  • Next to BRCA1 gene 2 protein
  • neighbor of BRCA1 gene 2 (non-protein coding)

Clone Names

  • MGC104305, DKFZp686F081

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003108.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC135721, BC034248, CR936675, U88573
    Related
    ENST00000460115.5
  2. NR_138145.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons and includes five alternate exons, compared to variant 1.
    Source sequence(s)
    AC135721, BC022065, BC034248
    Related
    ENST00000467245.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43125557..43153671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005821.4: Suppressed sequence

    Description
    NM_005821.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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