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NBR2 neighbor of BRCA1 lncRNA 2 [ Homo sapiens (human) ]

Gene ID: 10230, updated on 10-Oct-2023


Official Symbol
NBR2provided by HGNC
Official Full Name
neighbor of BRCA1 lncRNA 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000198496 MIM:618708; AllianceGenome:HGNC:20691
Gene type
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
Ubiquitous expression in thyroid (RPKM 6.8), spleen (RPKM 3.3) and 25 other tissues See more
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Genomic context

See NBR2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43125557..43153671)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43984189..44012426)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41277574..41305688)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41195058-41195600 Neighboring gene Rho family GTPase 2 Neighboring gene BRCA1 DNA repair associated Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:41214996-41215531 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41224055-41224260 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:41243136-41244335 Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene BRCA1 intronic recombination region Neighboring gene BRCA1 intron 2 regulatory region Neighboring gene BRCA1 promoter region Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:41298599-41299208 Neighboring gene uncharacterized LOC101929767 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 29 Neighboring gene BRCA1P1 intergenic recombination region Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41311429-41311959 Neighboring gene uncharacterized LOC124900391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12239 Neighboring gene BRCA1 pseudogene 1 Neighboring gene NBR1 autophagy cargo receptor

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Other Names

  • Neighbor of BRCA1 gene 2 protein
  • Next to BRCA1 gene 2 protein
  • neighbor of BRCA1 gene 2 (non-protein coding)

Clone Names

  • MGC104305, DKFZp686F081

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NR_003108.2 RNA Sequence

    Status: REVIEWED

    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC135721, BC034248, CR936675, U88573
  2. NR_138145.1 RNA Sequence

    Status: REVIEWED

    Transcript Variant: This variant (2) lacks two exons and includes five alternate exons, compared to variant 1.
    Source sequence(s)
    AC135721, BC022065, BC034248

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060941.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005821.4: Suppressed sequence

    NM_005821.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.