Format

Send to:

Choose Destination

KLRG1 killer cell lectin like receptor G1 [ Homo sapiens (human) ]

Gene ID: 10219, updated on 18-Aug-2020

Summary

Official Symbol
KLRG1provided by HGNC
Official Full Name
killer cell lectin like receptor G1provided by HGNC
Primary source
HGNC:HGNC:6380
See related
Ensembl:ENSG00000139187 MIM:604874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]
Expression
Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues See more
Orthologs

Genomic context

See KLRG1 in Genome Data Viewer
Location:
12p13.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (8950044..9215657)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9142137..9163343)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene alpha-2-macroglobulin like 1 Neighboring gene polyhomeotic homolog 1 Neighboring gene mannose-6-phosphate receptor, cation dependent Neighboring gene VDAC2 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 612 Neighboring gene A2M antisense RNA 1 Neighboring gene alpha-2-macroglobulin Neighboring gene keratin 17 pseudogene 8 Neighboring gene BTG anti-proliferation factor 1 pseudogene 1 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 12 Neighboring gene PZP alpha-2-macroglobulin like Neighboring gene microRNA 1244-3 Neighboring gene prothymosin alpha pseudogene 4 Neighboring gene alpha-2-macroglobulin pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
killer cell lectin-like receptor subfamily G member 1
Names
C-type lectin domain family 15 member A
ITIM-containing receptor MAFA-L
MAFA-like receptor
killer cell lectin-like receptor subfamily G, member 1
mast cell function-associated antigen (ITIM-containing)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329099.2NP_001316028.1  killer cell lectin-like receptor subfamily G member 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC006581, BC012621
    Consensus CDS
    CCDS86277.1
    UniProtKB/Swiss-Prot
    Q96E93
    Related
    ENSP00000266551.4, ENST00000266551.8
    Conserved Domains (1) summary
    cd03593
    Location:75186
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_001329101.2NP_001316030.1  killer cell lectin-like receptor subfamily G member 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC006581, DT217650
  3. NM_001329102.2NP_001316031.1  killer cell lectin-like receptor subfamily G member 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC006581
  4. NM_001329103.2NP_001316032.1  killer cell lectin-like receptor subfamily G member 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC006581
  5. NM_005810.4NP_005801.3  killer cell lectin-like receptor subfamily G member 1 isoform b

    See identical proteins and their annotated locations for NP_005801.3

    Status: REVIEWED

    Source sequence(s)
    AC006581, AF097358, AI433079, BC012621
    Consensus CDS
    CCDS8599.1
    UniProtKB/Swiss-Prot
    Q96E93
    Related
    ENSP00000349477.3, ENST00000356986.8
    Conserved Domains (1) summary
    cd03593
    Location:75186
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

  1. NR_137426.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006581
  2. NR_137427.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006581, BQ212545
  3. NR_137428.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006581

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    8950044..9215657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018685.1XP_016874174.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

  2. XM_017018684.1XP_016874173.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

  3. XM_017018683.1XP_016874172.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

  4. XM_017018682.1XP_016874171.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

Support Center