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CTDSPL CTD small phosphatase like [ Homo sapiens (human) ]

Gene ID: 10217, updated on 17-Jun-2019

Summary

Official Symbol
CTDSPLprovided by HGNC
Official Full Name
CTD small phosphatase likeprovided by HGNC
Primary source
HGNC:HGNC:16890
See related
Ensembl:ENSG00000144677 MIM:608592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSR1; SCP3; HYA22; RBSP3; C3orf8
Expression
Ubiquitous expression in skin (RPKM 20.1), gall bladder (RPKM 14.9) and 25 other tissues See more
Orthologs

Genomic context

See CTDSPL in Genome Data Viewer
Location:
3p22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (37861880..37984469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37903669..38025960)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 9 Neighboring gene VISTA enhancer hs1961 Neighboring gene ITGA9 antisense RNA 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 pseudogene 3 Neighboring gene HNF1 motif-containing MPRA enhancer 248 Neighboring gene Sharpr-MPRA regulatory region 7921 Neighboring gene microRNA 26a-1 Neighboring gene villin like Neighboring gene phospholipase C delta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CTD small phosphatase-like protein
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTDSP-like
NIF-like protein
NLI-interacting factor 1
RB protein serine phosphatase from chromosome 3
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
nuclear LIM interactor-interacting factor 1
small C-terminal domain phosphatase 3
small CTD phosphatase 3
NP_001008393.1
NP_005799.2
XP_016861008.1
XP_016861009.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008392.2NP_001008393.1  CTD small phosphatase-like protein isoform 1

    See identical proteins and their annotated locations for NP_001008393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093415, AC105752, AI143812, AJ575645
    Consensus CDS
    CCDS33734.1
    UniProtKB/Swiss-Prot
    O15194
    Related
    ENSP00000273179.5, ENST00000273179.10
    Conserved Domains (1) summary
    TIGR02251
    Location:106265
    HIF-SF_euk; Dullard-like phosphatase domain
  2. NM_005808.3NP_005799.2  CTD small phosphatase-like protein isoform 2

    See identical proteins and their annotated locations for NP_005799.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC093415, AC105752, AI192993, AJ575644
    Consensus CDS
    CCDS33735.1
    UniProtKB/Swiss-Prot
    O15194
    Related
    ENSP00000398288.2, ENST00000443503.6
    Conserved Domains (1) summary
    TIGR02251
    Location:95254
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    37861880..37984469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005519.1XP_016861008.1  CTD small phosphatase-like protein isoform X1

  2. XM_017005520.1XP_016861009.1  CTD small phosphatase-like protein isoform X2

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