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CTDSPL CTD small phosphatase like [ Homo sapiens (human) ]

Gene ID: 10217, updated on 17-Jun-2019

Summary

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Official Symbol
CTDSPLprovided by HGNC
Official Full Name
CTD small phosphatase likeprovided by HGNC
Primary source
HGNC:HGNC:16890
See related
Ensembl:ENSG00000144677 MIM:608592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSR1; SCP3; HYA22; RBSP3; C3orf8
Expression
Ubiquitous expression in skin (RPKM 20.1), gall bladder (RPKM 14.9) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See CTDSPL in Genome Data Viewer
Location:
3p22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (37861880..37984469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37903669..38025960)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 9 Neighboring gene VISTA enhancer hs1961 Neighboring gene ITGA9 antisense RNA 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 pseudogene 3 Neighboring gene HNF1 motif-containing MPRA enhancer 248 Neighboring gene Sharpr-MPRA regulatory region 7921 Neighboring gene microRNA 26a-1 Neighboring gene villin like Neighboring gene phospholipase C delta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma. Zhang L, et al. J Exp Clin Cancer Res, 2018 Jan 30. PMID 29382357, Free PMC Article
  2. RBSP3 is frequently altered in premalignant cervical lesions: clinical and prognostic significance. Mitra S, et al. Genes Chromosomes Cancer, 2010 Feb. PMID 19885927
  3. RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. Kashuba VI, et al. Proc Natl Acad Sci U S A, 2004 Apr 6. PMID 15051889, Free PMC Article
  4. [Interaction of two tumor suppressors: Phosphatase CTDSPL and Rb protein]. Beniaminov AD, et al. Mol Biol (Mosk), 2016 May-Jun. PMID 27414789
  5. MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Zheng YS, et al. Oncogene, 2012 Jan 5. PMID 21643017, Free PMC Article

See all (37) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. we have presented herein the novel finding that miR-181b contributes to cell cycle progression through depressing the expression of CTDSPL, which in turn activates the downstream effector E2F1 and promotes S-phase entry.
    Title: The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma.
  2. our data also suggests the importance ofLIMD1 and CDC25A in conjunction with HPV for use as diagnostic and prognostic markers of HNSCC, whereas RBSP3 as a prognostic marker only.
    Title: Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study.
  3. data suggest that overexpression of p-RB1 in basal-parabasal layers of normal cervical epithelium was due to methylation/low functional-linked non-synonimous SNPs of P16 and RBSP3. This pattern was maintained during cervical carcinogenesis by additional deletion/mutation
    Title: Association of P16-RBSP3 inactivation with phosphorylated RB1 overexpression in basal-parabasal layers of normal cervix unchanged during CACX development.
  4. CTDSPL and Rb directly interact and can be involved in the common mechanism of cell cycle regulation.
    Title: [Interaction of two tumor suppressors: Phosphatase CTDSPL and Rb protein].
  5. identified RBSP3, a phosphatase-like tumor suppressor, as a bona fide target of miR-100 and validated that RBSP3 was involved in cell differentiation and survival in acute myeloid leukemia
    Title: MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia.
  6. tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer
    Title: Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer.
  7. dysregulation of hMLH1, ITGA9, and RBSP3 associated multiple cellular pathways are needed for the development of early dysplastic lesions of the head and neck.
    Title: Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. In cervical intraepithelial neoplasms and uterine cervical carinoma, RBSP3 is oftne deletd, compared with other genes.
    Title: RBSP3 is frequently altered in premalignant cervical lesions: clinical and prognostic significance.
  10. This is the first report of high frequencies of somatic mutations in RASSF1 and RBSP3 in different cancers suggesting it may underlay the mutator phenotype of cancer.
    Title: High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
molecular_function ND
No biological Data available
more info
  
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
  
negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CTD small phosphatase-like protein
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTDSP-like
NIF-like protein
NLI-interacting factor 1
RB protein serine phosphatase from chromosome 3
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
nuclear LIM interactor-interacting factor 1
small C-terminal domain phosphatase 3
small CTD phosphatase 3
NP_001008393.1
NP_005799.2
XP_016861008.1
XP_016861009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008392.2 → NP_001008393.1  CTD small phosphatase-like protein isoform 1

    See identical proteins and their annotated locations for NP_001008393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093415, AC105752, AI143812, AJ575645
    Consensus CDS
    CCDS33734.1
    UniProtKB/Swiss-Prot
    O15194
    Related
    ENSP00000273179.5, ENST00000273179.10
    Conserved Domains (1) summary
    TIGR02251
    Location:106 → 265
    HIF-SF_euk; Dullard-like phosphatase domain

  2. NM_005808.3 → NP_005799.2  CTD small phosphatase-like protein isoform 2

    See identical proteins and their annotated locations for NP_005799.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC093415, AC105752, AI192993, AJ575644
    Consensus CDS
    CCDS33735.1
    UniProtKB/Swiss-Prot
    O15194
    Related
    ENSP00000398288.2, ENST00000443503.6
    Conserved Domains (1) summary
    TIGR02251
    Location:95 → 254
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    37861880..37984469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005519.1 → XP_016861008.1  CTD small phosphatase-like protein isoform X1

  2. XM_017005520.1 → XP_016861009.1  CTD small phosphatase-like protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15194.2 GenPept UniProtKB/Swiss-Prot:O15194

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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