HMGA2 high mobility group AT-hook 2 [Equus caballus (horse)] - Gene

Summary

Official Symbol: HMGA2provided by VGNC
Official Full Name: high mobility group AT-hook 2provided by VGNC
Primary source: VGNC:VGNC:56560
See related: Ensembl:ENSECAG00000040252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	TB-T2T (GCF_041296265.1)	6	NC_091689.1 (94526168..94655192)
RS_2024_08	previous assembly	EquCab3.0 (GCF_002863925.1)	6	NC_009149.3 (82552985..82681843)

Chromosome 6 - NC_091689.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Thoroughbred Stallion gene expression
BioProject: PRJEB53382
Analysis date: Mon Jan 06 09:53:19 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel Variants in the HMGA2 Gene Are Associated With Withers Height in Debao Pony.
Title: Novel Variants in the HMGA2 Gene Are Associated With Withers Height in Debao Pony.
In ponies, a probable functional mutation in HMGA2 had a frequency of 0.76, was strongly correlated with height (-0.75), and was low to moderately correlated with metabolic traits including: insulin, insulin after an oral sugar test, non-esterified fatty acids, and triglyceride concentrations.
Title: Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: high mobility group protein HMGI-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433493.1 → NP_001420422.1 high mobility group protein HMGI-C

Status: VALIDATED

Source sequence(s)

JBFNWK010000006

UniProtKB/TrEMBL

A0A0P1CZ40

RefSeqs of Annotated Genomes: GCF_041296265.1-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TB-T2T Primary Assembly

Genomic

NC_091689.1 Reference TB-T2T Primary Assembly

Range

94526168..94655192

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_070269209.1 → XP_070125310.1 high mobility group protein HMGI-C isoform X2

UniProtKB/TrEMBL

A0A0P1CZ40
XM_023643958.2 → XP_023499726.1 high mobility group protein HMGI-C isoform X1

UniProtKB/TrEMBL

F6SE95

Related

ENSECAP00000022776.2

Conserved Domains (1) summary

cl25438
Location:3 → 75

RNB; RNB domain