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SSX3 SSX family member 3 [ Homo sapiens (human) ]

Gene ID: 10214, updated on 12-Oct-2019

Summary

Official Symbol
SSX3provided by HGNC
Official Full Name
SSX family member 3provided by HGNC
Primary source
HGNC:HGNC:11337
See related
Ensembl:ENSG00000165584 MIM:300325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT5.3
Summary
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]
Expression
Restricted expression toward testis (RPKM 5.8) See more
Orthologs

Genomic context

See SSX3 in Genome Data Viewer
Location:
Xp11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48346427..48356706, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48205863..48216203, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SSX family pseudogene 9 Neighboring gene protein S100-A11 pseudogene Neighboring gene ornithine aminotransferase pseudogene Neighboring gene ornithine aminotransferase, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14495, MGC119054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein SSX3
Names
Kruppel-associated box containing gene product SSX3
cancer/testis antigen 5.3
synovial sarcoma, X breakpoint 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012561.1 RefSeqGene

    Range
    5005..15281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021014.4NP_066294.1  protein SSX3

    See identical proteins and their annotated locations for NP_066294.1

    Status: REVIEWED

    Source sequence(s)
    AA609599, AL606490, BC103862, U90840
    Consensus CDS
    CCDS14291.1
    UniProtKB/Swiss-Prot
    Q99909
    Related
    ENSP00000298396.2, ENST00000298396.7
    Conserved Domains (2) summary
    smart00349
    Location:2382
    KRAB; krueppel associated box
    pfam09514
    Location:156187
    SSXRD; SSXRD motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48346427..48356706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543885.2XP_011542187.1  protein SSX3 isoform X1

    See identical proteins and their annotated locations for XP_011542187.1

    UniProtKB/Swiss-Prot
    Q99909
    UniProtKB/TrEMBL
    A0A024R1B1
    Related
    ENSP00000366090.3, ENST00000376893.7
    Conserved Domains (1) summary
    smart00349
    Location:2382
    KRAB; krueppel associated box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175711.1: Suppressed sequence

    Description
    NM_175711.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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