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FLOT1 flotillin 1 [ Homo sapiens (human) ]

Gene ID: 10211, updated on 5-Jul-2020

Summary

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Official Symbol
FLOT1provided by HGNC
Official Full Name
flotillin 1provided by HGNC
Primary source
HGNC:HGNC:3757
See related
Ensembl:ENSG00000137312 MIM:606998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in adrenal (RPKM 66.3), heart (RPKM 56.6) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See FLOT1 in Genome Data Viewer
Location:
6p21.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30727709..30742851, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30695506..30710687, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene MDC1 antisense RNA 1 Neighboring gene tubulin beta class I Neighboring gene IER3 antisense RNA 1 Neighboring gene immediate early response 3 Neighboring gene RNA, 7SL, cytoplasmic 353, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma. Zhang L, et al. Thorac Cancer, 2019 Apr. PMID 30838797, Free PMC Article
  2. Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder. Zhong J, et al. Neuropsychopharmacology, 2019 Aug. PMID 30771789,
  3. Flotillin 1 is differentially expressed in human epithelial ovarian tumors. Li J, et al. Neoplasma, 2018. PMID 30064230
  4. Flotilin-1 promotes the tumorigenicity and progression of malignant phenotype in human lung adenocarcinoma. Guo AY, et al. Cancer Biol Ther, 2017 Sep 2. PMID 28825855, Free PMC Article
  5. Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis. Hahn S, et al. J Neuroinflammation, 2017 Jun 23. PMID 28645295, Free PMC Article

See all (160) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study identified FLOT1 as a novel MDD risk gene whose expression level may play a role in MDD. In addition, our findings also suggest that risk variants may confer risk of MDD through affecting expression of FLOT1.
    Title: Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.
  2. Results show that FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle in lung adenocarcinoma by simultaneously affecting the Erk and Akt signaling pathways.
    Title: FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma.
  3. the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported.
    Title: Flotillins in the intercalated disc are potential modulators of cardiac excitability.
  4. FLOT1 protein expression was significantly associated with serous epithelial ovarian tumor
    Title: Flotillin 1 is differentially expressed in human epithelial ovarian tumors.
  5. A new mechanism of sumoylated Flot-1-mediating Snail stabilization is presented.
    Title: Sumoylation of Flotillin-1 promotes EMT in metastatic prostate cancer by suppressing Snail degradation.
  6. Together, the data revealed that FLOT1 and FLOT2 are crucial for Anaplasma replication in host cells, likely by aiding vesicular traffic of low-density lipoprotein-derived free cholesterol to Anaplasma inclusions.
    Title: Infection by Anaplasma phagocytophilum Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins.
  7. Results showed that flotillin-1 and flotillin-2 expression were upregulated in HCCLM3 cells following 45 degrees C heat treatment and in residual HCCLM3 xenografts cells after insufficient RFA.
    Title: Insufficient radiofrequency ablation promotes the metastasis of residual hepatocellular carcinoma cells via upregulating flotillin proteins.
  8. flotillin-1 is a tumorigenic protein that plays an important role in promoting the proliferation and tumorigenicity of LUAD.
    Title: Flotilin-1 promotes the tumorigenicity and progression of malignant phenotype in human lung adenocarcinoma.
  9. flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes
    Title: Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes.
  10. Autoantibodies against flotillin-1/2 heterocomplex are present in 1-2% of patients with bona fide multiple sclerosis.
    Title: Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genetic predictors of medically refractory ulcerative colitis.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Immunoblot of sucrose fractions to lipid raft marker Flotillin-1 and non-lipid raft marker TfR shows that HIV-1 Gag and Env interact with both Flotillin-1 and TfR in cells PubMed
env HIV-1 gp160 is identified to have a physical interaction with flotillin 1 (FLOT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with flotillin 1 (FLOT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Immunoblot of sucrose fractions to lipid raft marker Flotillin-1 and non-lipid raft marker TfR shows that HIV-1 Gag and Env interact with both Flotillin-1 and TfR in cells PubMed
Tat tat HIV-1 Tat co-localizes with APP and promotes localization of APP to lipid rafts with flotillin-1 in HIV-1 infected U-87 MG cells PubMed
Vpu vpu HIV-1 Vpu predominantly co-localizes to the detergent-soluble fractions with a non-raft protein TfR and partially partitions to the detergent-resistant membrane fractions with a raft protein flotillin 1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
  
protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
  
cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
dsRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
plasma membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cell adhesion molecule production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cell junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of synaptic transmission, dopaminergic ISS
Inferred from Sequence or Structural Similarity
more info
  
positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein localization to membrane raft IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
regulation of neurotransmitter uptake IDA
Inferred from Direct Assay
more info
 PubMed 
regulation of neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
NOT apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
caveola TAS
Traceable Author Statement
more info
 PubMed 
cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
dopaminergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
endosome IDA
Inferred from Direct Assay
more info
 PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
extracellular exosome HDA PubMed 
flotillin complex IDA
Inferred from Direct Assay
more info
 PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
lysosomal membrane HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
  
membrane HDA PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
  
sarcolemma IEA
Inferred from Electronic Annotation
more info
  
uropod IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
flotillin-1
Names
integral membrane component of caveolae

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318875.1 → NP_001305804.1  flotillin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF117234, AK301291, HY101236
    UniProtKB/Swiss-Prot
    O75955
    Conserved Domains (2) summary
    cd03399
    Location:30 → 127
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl19107
    Location:193 → 299
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_005803.4 → NP_005794.1  flotillin-1 isoform 1

    See identical proteins and their annotated locations for NP_005794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF089750, AF117234, HY101236
    Consensus CDS
    CCDS4688.1
    UniProtKB/Swiss-Prot
    O75955
    UniProtKB/TrEMBL
    Q5ST80
    Related
    ENSP00000365569.3, ENST00000376389.8
    Conserved Domains (2) summary
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:4 → 419
    Flot; Flotillin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30727709..30742851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714947.3 → XP_006715010.1  flotillin-1 isoform X4

    See identical proteins and their annotated locations for XP_006715010.1

    Conserved Domains (3) summary
    smart00244
    Location:31 → 213
    PHB; prohibitin homologues
    cd03399
    Location:18 → 122
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl19107
    Location:188 → 294
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_005248780.3 → XP_005248837.1  flotillin-1 isoform X1

    See identical proteins and their annotated locations for XP_005248837.1

    UniProtKB/Swiss-Prot
    O75955
    UniProtKB/TrEMBL
    Q5ST80
    Conserved Domains (2) summary
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:4 → 419
    Flot; Flotillin

  3. XM_017010158.1 → XP_016865647.1  flotillin-1 isoform X3

  4. XM_017010157.1 → XP_016865646.1  flotillin-1 isoform X2

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2057212..2060006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2207446..2222591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1983559..1998702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    2037960..2053102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    2071784..2085411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1982822..1997961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    2028495..2043647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75955.3 GenPept UniProtKB/Swiss-Prot:O75955

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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