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USPL1 ubiquitin specific peptidase like 1 [ Homo sapiens (human) ]

Gene ID: 10208, updated on 6-Jul-2025
Official Symbol
USPL1provided by HGNC
Official Full Name
ubiquitin specific peptidase like 1provided by HGNC
Primary source
HGNC:HGNC:20294
See related
Ensembl:ENSG00000132952 MIM:617470; AllianceGenome:HGNC:20294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C13orf22; D13S106E; bA121O19.1
Summary
Enables SUMO binding activity and deSUMOylase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 10.5), bone marrow (RPKM 8.9) and 25 other tissues See more
Orthologs
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See USPL1 in Genome Data Viewer
Location:
13q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (30617920..30660766)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (29839977..29882805)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31192057..31234903)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 Neighboring gene microfibril associated protein 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3331 Neighboring gene PTPN2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31233439-31234198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5236 Neighboring gene tRNA-Asn (anticodon GTT) 2-4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7544 Neighboring gene MPRA-validated peak2063 silencer Neighboring gene uncharacterized LOC124903146 Neighboring gene arachidonate 5-lipoxygenase activating protein Neighboring gene ReSE screen-validated silencer GRCh37_chr13:31312711-31312902 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:31317812-31319011

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ32952, DKFZp781K2286

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SUMO binding IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables deSUMOylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Cajal body organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Cajal body organization IEA
Inferred from Electronic Annotation
more info
 
involved_in Cajal body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in snRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SUMO-specific isopeptidase USPL1
Names
USP-like 1
highly charged protein
ubiquitin-specific peptidase-like protein 1
NP_001308461.1
NP_001308462.1
NP_001308463.1
NP_005791.3
XP_006719814.1
XP_016875803.1
XP_016875804.1
XP_047285983.1
XP_047285984.1
XP_047285985.1
XP_047285986.1
XP_047285987.1
XP_047285988.1
XP_054229966.1
XP_054229967.1
XP_054229968.1
XP_054229969.1
XP_054229970.1
XP_054229971.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321532.2NP_001308461.1  SUMO-specific isopeptidase USPL1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK289826, AL138681, BC036027, CR627370, DB288223, X59131
    UniProtKB/TrEMBL
    B3KQ64
    Conserved Domains (2) summary
    pfam15499
    Location:47317
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:391909
    DUF4650; Domain of unknown function (DUF4650)
  2. NM_001321533.2NP_001308462.1  SUMO-specific isopeptidase USPL1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL138681, CR627370, DB288223
    Consensus CDS
    CCDS81760.1
    UniProtKB/TrEMBL
    B3KQ64
    Related
    ENSP00000480656.1, ENST00000614860.1
    Conserved Domains (2) summary
    pfam15499
    Location:1169
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:243761
    DUF4650; Domain of unknown function (DUF4650)
  3. NM_001321534.2NP_001308463.1  SUMO-specific isopeptidase USPL1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK057514, AL138681, CR627370
    Consensus CDS
    CCDS81760.1
    UniProtKB/TrEMBL
    B3KQ64
    Conserved Domains (2) summary
    pfam15499
    Location:1169
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:243761
    DUF4650; Domain of unknown function (DUF4650)
  4. NM_005800.5NP_005791.3  SUMO-specific isopeptidase USPL1 isoform 1

    See identical proteins and their annotated locations for NP_005791.3

    Status: VALIDATED

    Source sequence(s)
    AK289826, AL138681, BC036027, BI752017, X59131
    Consensus CDS
    CCDS9336.1
    UniProtKB/Swiss-Prot
    Q14109, Q5W0Q7, Q6AI45, Q8IY30, Q8IYE8
    UniProtKB/TrEMBL
    A8K1B1
    Related
    ENSP00000255304.4, ENST00000255304.9
    Conserved Domains (2) summary
    pfam15499
    Location:228498
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:5721090
    DUF4650; Domain of unknown function (DUF4650)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    30617920..30660766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430027.1XP_047285983.1  SUMO-specific isopeptidase USPL1 isoform X1

    UniProtKB/Swiss-Prot
    Q14109, Q5W0Q7, Q6AI45, Q8IY30, Q8IYE8
    UniProtKB/TrEMBL
    A8K1B1
  2. XM_047430028.1XP_047285984.1  SUMO-specific isopeptidase USPL1 isoform X1

    UniProtKB/Swiss-Prot
    Q14109, Q5W0Q7, Q6AI45, Q8IY30, Q8IYE8
    UniProtKB/TrEMBL
    A8K1B1
  3. XM_047430031.1XP_047285987.1  SUMO-specific isopeptidase USPL1 isoform X5

    UniProtKB/TrEMBL
    B3KQ64
  4. XM_017020314.3XP_016875803.1  SUMO-specific isopeptidase USPL1 isoform X3

    UniProtKB/TrEMBL
    A8K1B1
  5. XM_006719751.5XP_006719814.1  SUMO-specific isopeptidase USPL1 isoform X2

    UniProtKB/TrEMBL
    A8K1B1
    Conserved Domains (2) summary
    pfam15499
    Location:222492
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:5661084
    DUF4650; Domain of unknown function (DUF4650)
  6. XM_047430032.1XP_047285988.1  SUMO-specific isopeptidase USPL1 isoform X6

  7. XM_017020315.2XP_016875804.1  SUMO-specific isopeptidase USPL1 isoform X4

    UniProtKB/TrEMBL
    B3KQ64
  8. XM_047430029.1XP_047285985.1  SUMO-specific isopeptidase USPL1 isoform X2

    UniProtKB/TrEMBL
    A8K1B1
  9. XM_047430030.1XP_047285986.1  SUMO-specific isopeptidase USPL1 isoform X5

    UniProtKB/TrEMBL
    B3KQ64

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    29839977..29882805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373991.1XP_054229966.1  SUMO-specific isopeptidase USPL1 isoform X1

    UniProtKB/TrEMBL
    A8K1B1
  2. XM_054373995.1XP_054229970.1  SUMO-specific isopeptidase USPL1 isoform X5

    UniProtKB/TrEMBL
    B3KQ64
  3. XM_054373993.1XP_054229968.1  SUMO-specific isopeptidase USPL1 isoform X3

    UniProtKB/TrEMBL
    A8K1B1
  4. XM_054373992.1XP_054229967.1  SUMO-specific isopeptidase USPL1 isoform X2

    UniProtKB/TrEMBL
    A8K1B1
  5. XM_054373996.1XP_054229971.1  SUMO-specific isopeptidase USPL1 isoform X6

  6. XM_054373994.1XP_054229969.1  SUMO-specific isopeptidase USPL1 isoform X4

    UniProtKB/TrEMBL
    B3KQ64