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DHRS2 dehydrogenase/reductase 2 [ Homo sapiens (human) ]

Gene ID: 10202, updated on 11-Sep-2019

Summary

Official Symbol
DHRS2provided by HGNC
Official Full Name
dehydrogenase/reductase 2provided by HGNC
Primary source
HGNC:HGNC:18349
See related
Ensembl:ENSG00000100867 MIM:615194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEP27; SDR25C1
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Expression
Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues See more
Orthologs

Genomic context

See DHRS2 in Genome Data Viewer
Location:
14q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23630115..23645639)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24099324..24114848)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724814 Neighboring gene junctophilin 4 Neighboring gene Sharpr-MPRA regulatory region 10629 Neighboring gene uncharacterized LOC105370407 Neighboring gene uncharacterized LOC105370408

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20338

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
C21-steroid hormone metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
myeloid dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 2, mitochondrial
Names
dehydrogenase/reductase (SDR family) member 2
dehydrogenase/reductase member 2
dicarbonyl reductase HEP27
protein D
short chain dehydrogenase/reductase family 25C member 1
short-chain alcohol dehydrogenase family member

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318835.1NP_001305764.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 1. This results in a protein that is shorter at the C-terminus, compared to isoform 1. The promoter used by this transcript is a hepatocyte specific promoter.
    Source sequence(s)
    AK309975, AL135999
    Conserved Domains (1) summary
    cl21454
    Location:27140
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_005794.4NP_005785.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_005785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). The promoter used by this transcript is a hepatocyte-specific promoter.
    Source sequence(s)
    AK222857, U31875
    Consensus CDS
    CCDS9604.1
    UniProtKB/Swiss-Prot
    Q13268
    Related
    ENSP00000250383.6, ENST00000250383.10
    Conserved Domains (2) summary
    PRK07231
    Location:34275
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:27275
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_182908.4NP_878912.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_878912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR. (PMID: 11944995) This promoter is specifically active in human monocyte-derived dendritic cells.
    Source sequence(s)
    AL135999, BC002786
    Consensus CDS
    CCDS41927.1
    UniProtKB/Swiss-Prot
    Q13268
    Related
    ENSP00000344674.7, ENST00000344777.11
    Conserved Domains (1) summary
    cl25409
    Location:27226
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23630115..23645639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267249.1XP_005267306.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005267306.1

    UniProtKB/Swiss-Prot
    Q13268
    Related
    ENSP00000401213.2, ENST00000432832.6
    Conserved Domains (2) summary
    PRK07231
    Location:34275
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:27275
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_006720001.3XP_006720064.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006720064.1

    UniProtKB/Swiss-Prot
    Q13268
    Conserved Domains (2) summary
    PRK07231
    Location:34275
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cl21454
    Location:27275
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_011536339.2XP_011534641.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011534641.1

    Related
    ENSP00000451895.1, ENST00000557535.5
    Conserved Domains (1) summary
    cl21454
    Location:1199
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_011536338.1XP_011534640.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011534640.1

    Conserved Domains (1) summary
    cl21454
    Location:1199
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_001750107.1 RNA Sequence

    Related
    ENST00000556701.5
  2. XR_943366.2 RNA Sequence

  3. XR_001750106.1 RNA Sequence

  4. XR_943367.2 RNA Sequence

  5. XR_001750105.1 RNA Sequence

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