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DHRS2 dehydrogenase/reductase 2 [ Homo sapiens (human) ]

Gene ID: 10202, updated on 10-Dec-2024

Summary

Official Symbol
DHRS2provided by HGNC
Official Full Name
dehydrogenase/reductase 2provided by HGNC
Primary source
HGNC:HGNC:18349
See related
Ensembl:ENSG00000100867 MIM:615194; AllianceGenome:HGNC:18349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEP27; SDR25C1
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Expression
Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues See more
Orthologs
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Genomic context

See DHRS2 in Genome Data Viewer
Location:
14q11.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23630115..23645639)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17830743..17846267)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24099324..24114848)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thiamine triphosphatase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24031286-24031786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24031787-24032287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5611 Neighboring gene AP1G2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24046010-24046770 Neighboring gene adaptor related protein complex 1 subunit gamma 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24054355-24054854 Neighboring gene junctophilin 4 Neighboring gene Sharpr-MPRA regulatory region 10629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8178 Neighboring gene uncharacterized LOC105370407 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:24139233-24140432 Neighboring gene uncharacterized LOC105370408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24163587-24164103

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20338

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 2, mitochondrial
Names
dehydrogenase/reductase (SDR family) member 2
dehydrogenase/reductase member 2
dicarbonyl reductase HEP27
protein D
short chain dehydrogenase/reductase family 25C member 1
short-chain alcohol dehydrogenase family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318835.1NP_001305764.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 1. This results in a protein that is shorter at the C-terminus, compared to isoform 1. The promoter used by this transcript is a hepatocyte specific promoter.
    Source sequence(s)
    AK309975, AL135999
    UniProtKB/TrEMBL
    Q59F08
    Related
    ENST00000553896.5
    Conserved Domains (1) summary
    cl21454
    Location:27140
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_005794.4NP_005785.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_005785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). The promoter used by this transcript is a hepatocyte-specific promoter.
    Source sequence(s)
    AK222857, U31875
    Consensus CDS
    CCDS9604.1
    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6
    Related
    ENSP00000250383.7, ENST00000250383.11
    Conserved Domains (1) summary
    cl21454
    Location:27275
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_182908.5NP_878912.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_878912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR. (PMID: 11944995) This promoter is specifically active in human monocyte-derived dendritic cells.
    Source sequence(s)
    AL135999, BC002786
    Consensus CDS
    CCDS41927.1
    UniProtKB/Swiss-Prot
    Q13268
    Related
    ENSP00000344674.7, ENST00000344777.11
    Conserved Domains (1) summary
    cl25409
    Location:27226
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23630115..23645639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267249.1XP_005267306.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005267306.1

    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6
    Related
    ENSP00000401213.2, ENST00000432832.6
    Conserved Domains (1) summary
    cl21454
    Location:27275
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011536339.3XP_011534641.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011534641.1

    UniProtKB/TrEMBL
    H0YJP4
    Related
    ENSP00000451895.1, ENST00000557535.5
    Conserved Domains (1) summary
    cl21454
    Location:1199
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_006720001.4XP_006720064.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006720064.1

    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6
    Conserved Domains (1) summary
    cl21454
    Location:27275
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_011536338.2XP_011534640.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011534640.1

    UniProtKB/TrEMBL
    H0YJP4
    Conserved Domains (1) summary
    cl21454
    Location:1199
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_047430874.1XP_047286830.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6

RNA

  1. XR_007063975.1 RNA Sequence

  2. XR_007063976.1 RNA Sequence

  3. XR_007063974.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17830743..17846267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375248.1XP_054231223.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6
  2. XM_054375252.1XP_054231227.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    H0YJP4
  3. XM_054375249.1XP_054231224.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6
  4. XM_054375251.1XP_054231226.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    H0YJP4
  5. XM_054375250.1XP_054231225.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
    UniProtKB/TrEMBL
    C9JZP6

RNA

  1. XR_008488811.1 RNA Sequence

  2. XR_008488812.1 RNA Sequence

  3. XR_008488810.1 RNA Sequence