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MPHOSPH10 M-phase phosphoprotein 10 [ Homo sapiens (human) ]

Gene ID: 10199, updated on 21-Nov-2020

Summary

Official Symbol
MPHOSPH10provided by HGNC
Official Full Name
M-phase phosphoprotein 10provided by HGNC
Primary source
HGNC:HGNC:7213
See related
Ensembl:ENSG00000124383 MIM:605503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT90; MPP10; MPP10P; PPP1R106
Summary
This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in esophagus (RPKM 13.3), prostate (RPKM 12.5) and 25 other tissues See more
Orthologs

Genomic context

See MPHOSPH10 in Genome Data Viewer
Location:
2p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (71130634..71150101)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71357444..71377232)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine kinase Neighboring gene methylmalonyl-CoA epimerase Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene uncharacterized LOC105374797

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing NAS
Non-traceable Author Statement
more info
PubMed 
RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
RNA splicing, via transesterification reactions NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
small nucleolar ribonucleoprotein complex NAS
Non-traceable Author Statement
more info
PubMed 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
U3 small nucleolar ribonucleoprotein protein MPP10
Names
U3 small nucleolar ribonucleoprotein
m phase phosphoprotein 10
protein phosphatase 1, regulatory subunit 106

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005791.3NP_005782.1  U3 small nucleolar ribonucleoprotein protein MPP10

    See identical proteins and their annotated locations for NP_005782.1

    Status: REVIEWED

    Source sequence(s)
    BC041084, BC126389
    Consensus CDS
    CCDS1916.1
    UniProtKB/Swiss-Prot
    O00566
    Related
    ENSP00000244230.2, ENST00000244230.7
    Conserved Domains (1) summary
    pfam04006
    Location:22632
    Mpp10; Mpp10 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    71130634..71150101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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