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MPHOSPH9 M-phase phosphoprotein 9 [ Homo sapiens (human) ]

Gene ID: 10198, updated on 7-Oct-2018

Summary

Official Symbol
MPHOSPH9provided by HGNC
Official Full Name
M-phase phosphoprotein 9provided by HGNC
Primary source
HGNC:HGNC:7215
See related
Ensembl:ENSG00000051825 MIM:605501; Vega:OTTHUMG00000168849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPP9; MPP-9
Expression
Broad expression in bone marrow (RPKM 6.2), testis (RPKM 5.8) and 24 other tissues See more
Orthologs

Genomic context

See MPHOSPH9 in Genome Data Viewer
Location:
12q24.31
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (123152324..123244014, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123640943..123717785, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein membrane associated 2 Neighboring gene microRNA 4304 Neighboring gene PITPNM2 antisense RNA 1 Neighboring gene chromosome 12 open reading frame 65 Neighboring gene cyclin dependent kinase 2 associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 375

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with MPHOSPH9 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12954, DKFZp434J034

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022782.3NP_073619.3  M-phase phosphoprotein 9

    See identical proteins and their annotated locations for NP_073619.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein. This variant lacks full-length human transcript support but is supported by tiled partial transcript data and by homologous transcripts.
    Source sequence(s)
    AK091181, BC130440, BF793354, CX782912, DB071469, DB111293
    Consensus CDS
    CCDS9243.2
    UniProtKB/Swiss-Prot
    Q99550
    Related
    ENSP00000475489.1, OTTHUMP00000273786, ENST00000606320.5, OTTHUMT00000471390
    Conserved Domains (1) summary
    pfam15035
    Location:621795
    Rootletin; Ciliary rootlet component, centrosome cohesion

RNA

  1. NR_103517.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional internal exon, lacks a different internal exon, and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073857, AK091181, AK096541, BF793354, DB071469, DB111293
    Related
    ENST00000545556.6, OTTHUMT00000401359

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    123152324..123244014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537741.2XP_011536043.1  M-phase phosphoprotein 9 isoform X2

    See identical proteins and their annotated locations for XP_011536043.1

    Conserved Domains (1) summary
    pfam15035
    Location:621795
    Rootletin; Ciliary rootlet component, centrosome cohesion
  2. XM_011537740.2XP_011536042.1  M-phase phosphoprotein 9 isoform X2

    See identical proteins and their annotated locations for XP_011536042.1

    Conserved Domains (1) summary
    pfam15035
    Location:621795
    Rootletin; Ciliary rootlet component, centrosome cohesion
  3. XM_017018677.1XP_016874166.1  M-phase phosphoprotein 9 isoform X6

    Conserved Domains (1) summary
    pfam15035
    Location:621795
    Rootletin; Ciliary rootlet component, centrosome cohesion
  4. XM_017018673.1XP_016874162.1  M-phase phosphoprotein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q99550
    Conserved Domains (1) summary
    pfam15035
    Location:621795
    Rootletin; Ciliary rootlet component, centrosome cohesion
  5. XM_024448794.1XP_024304562.1  M-phase phosphoprotein 9 isoform X9

    Conserved Domains (1) summary
    cl25732
    Location:219425
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_017018680.1XP_016874169.1  M-phase phosphoprotein 9 isoform X8

    UniProtKB/Swiss-Prot
    Q99550
    Conserved Domains (1) summary
    cl25732
    Location:440646
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_017018675.1XP_016874164.1  M-phase phosphoprotein 9 isoform X4

    Conserved Domains (1) summary
    pfam15035
    Location:579753
    Rootletin; Ciliary rootlet component, centrosome cohesion
  8. XM_017018676.1XP_016874165.1  M-phase phosphoprotein 9 isoform X5

    Conserved Domains (2) summary
    pfam15035
    Location:586743
    Rootletin; Ciliary rootlet component, centrosome cohesion
    pfam15619
    Location:592743
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
  9. XM_017018674.1XP_016874163.1  M-phase phosphoprotein 9 isoform X3

  10. XM_017018681.1XP_016874170.1  M-phase phosphoprotein 9 isoform X9

    Conserved Domains (1) summary
    cl25732
    Location:219425
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_017018678.1XP_016874167.1  M-phase phosphoprotein 9 isoform X7

  12. XM_017018679.1XP_016874168.1  M-phase phosphoprotein 9 isoform X8

    UniProtKB/Swiss-Prot
    Q99550
    Conserved Domains (1) summary
    cl25732
    Location:440646
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_001748539.1 RNA Sequence

  2. XR_001748541.1 RNA Sequence

  3. XR_001748543.1 RNA Sequence

  4. XR_001748542.1 RNA Sequence

  5. XR_001748540.1 RNA Sequence

  6. XR_001748544.1 RNA Sequence

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