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HSFX4 heat shock transcription factor family, X-linked member 4 [ Homo sapiens (human) ]

Gene ID: 101927685, updated on 13-May-2022

Summary

Official Symbol
HSFX4provided by HGNC
Official Full Name
heat shock transcription factor family, X-linked member 4provided by HGNC
Primary source
HGNC:HGNC:52398
See related
Ensembl:ENSG00000283463 AllianceGenome:HGNC:52398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 16.2), adrenal (RPKM 10.0) and 24 other tissues See more
Orthologs
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Genomic context

See HSFX4 in Genome Data Viewer
Location:
Xq28
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149929573..149931287)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (148197199..148198913)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (149097791..149099505)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 850 Neighboring gene MAGEA8 antisense RNA 1 Neighboring gene MAGE family member A8 Neighboring gene EOLA2 divergent transcript Neighboring gene endothelium and lymphocyte associated ASCH domain 2 Neighboring gene nucleolar protein 11 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heat shock transcription factor, X-linked member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351114.2NP_001338043.1  heat shock transcription factor, X-linked member 4

    Status: VALIDATED

    Source sequence(s)
    AC244099
    Consensus CDS
    CCDS87786.1
    Related
    ENSP00000489814.2, ENST00000457775.3
    Conserved Domains (1) summary
    pfam00447
    Location:83182
    HSF_DNA-bind; HSF-type DNA-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    149929573..149931287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    148197199..148198913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)