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NCK1-DT NCK1 divergent transcript [ Homo sapiens (human) ]

Gene ID: 101927597, updated on 19-Feb-2023

Summary

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Official Symbol
NCK1-DTprovided by HGNC
Official Full Name
NCK1 divergent transcriptprovided by HGNC
Primary source
HGNC:HGNC:49645
See related
AllianceGenome:HGNC:49645
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCK1-AS1; SLC35G2-AS1
Expression
Ubiquitous expression in lymph node (RPKM 2.8), spleen (RPKM 2.7) and 25 other tissues See more
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Genomic context

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See NCK1-DT in Genome Data Viewer
Location:
3q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136841976..136862063, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139582626..139602716, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136560818..136580905, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene stromal antigen 1 Neighboring gene RNA, U6 small nuclear 789, pseudogene Neighboring gene DNAJC8 pseudogene 2 Neighboring gene solute carrier family 35 member G2 Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene NCK adaptor protein 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene interleukin 20 receptor subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis. He XY, et al. Cell Cycle, 2023 Mar. PMID 36412985,
  2. LncRNA NCK1-AS1-mediated regulatory functions in human diseases. Wang Y, et al. Clin Transl Oncol, 2023 Feb. PMID 36131072
  3. LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling. Zhou W, et al. J Gastrointestin Liver Dis, 2022 Mar 19. PMID 35306563
  4. LncRNA NCK1-AS1 promotes proliferation and induces cell cycle progression by crosstalk NCK1-AS1/miR-6857/CDK1 pathway. Li H, et al. Cell Death Dis, 2018 Feb 7. PMID 29416014, Free PMC Article
  5. NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC. Zhou X, et al. Cancer Biol Ther, 2021 Mar 4. PMID 33629937, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis.
    Title: Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis.
  2. LncRNA NCK1-AS1-mediated regulatory functions in human diseases.
    Title: LncRNA NCK1-AS1-mediated regulatory functions in human diseases.
  3. LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling.
    Title: LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling.
  4. NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC.
    Title: NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC.
  5. Upregulation of lncRNA NCK1-AS1 predicts poor prognosis and contributes to non-small cell lung cancer proliferation by regulating CDK1.
    Title: Upregulation of lncRNA NCK1-AS1 predicts poor prognosis and contributes to non-small cell lung cancer proliferation by regulating CDK1.
  6. LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis.
    Title: LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis.
  7. NCK1-AS1 Increases Drug Resistance of Glioma Cells to Temozolomide by Modulating miR-137/TRIM24.
    Title: NCK1-AS1 Increases Drug Resistance of Glioma Cells to Temozolomide by Modulating miR-137/TRIM24.
  8. NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
    Title: NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
  9. NCK1-AS1 functioned as a molecular sponge for miR-6857, antagonizing its ability to repress CDK1/6 protein translation. Findings suggest that NCK1-AS1/miR-6857/CDK1 crosstalk serve as a critical effector in cervical cancer progression.
    Title: LncRNA NCK1-AS1 promotes proliferation and induces cell cycle progression by crosstalk NCK1-AS1/miR-6857/CDK1 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • NCK1 antisense RNA 1 (head to head)
  • SLC35G2 antisense RNA 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110175.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AA708729, AC011597, HY007950

  2. NR_110176.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an internal exon resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AA708729, AC011597, CB047433

  3. NR_110177.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AA708729, AC011597, DA714434, HY007950

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    136841976..136862063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    139582626..139602716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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