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akt1 v-akt murine thymoma viral oncogene homolog 1 [ Danio rerio (zebrafish) ]

Gene ID: 101910198, updated on 9-Sep-2025
Official Symbol
akt1provided by ZNC
Official Full Name
v-akt murine thymoma viral oncogene homolog 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-130730-1
See related
AllianceGenome:ZFIN:ZDB-GENE-130730-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of neuron differentiation and regulation of blood vessel endothelial cell differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; hindbrain neural rod; pharyngeal arch; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); gastrointestinal system cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See akt1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 17 NC_133192.1 (2574325..2674616)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 17 NC_007128.7 (1437407..1537044)

Chromosome 17 - NC_133192.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141378500 Neighboring gene SIVA1, apoptosis-inducing factor Neighboring gene uncharacterized LOC141378497 Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene centrosomal protein 170Ba

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Receptor-Mediated AKT/PI3K Signalling and Behavioural Alterations in Zebrafish Larvae Reveal Association between Schizophrenia and Opioid Use Disorder. Thiagarajan SK, et al. Int J Mol Sci, 2022 Apr 25. PMID 35563106, Free PMC Article
  2. Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine. Perna AF, et al. Int J Mol Sci, 2018 Apr 29. PMID 29710830, Free PMC Article
  3. Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish. Zhang L, et al. Int J Mol Sci, 2024 Sep 1. PMID 39273457, Free PMC Article
  4. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. Jeffery J, et al. FASEB J, 2015 May. PMID 25667221
  5. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos. Li L, et al. Life Sci, 2016 Jul 15. PMID 27234894

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study has identified Akt as a novel intracellular pathway required for neural crest differentiation.
    Title: A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.
  2. Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
    Title: Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of blood vessel endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
RAC-alpha serine/threonine-protein kinase
NP_001268730.1
XP_021322776.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281801.1 → NP_001268730.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001268730.1

    Status: PROVISIONAL

    Source sequence(s)
    JX307852
    UniProtKB/TrEMBL
    M4MD44
    Conserved Domains (2) summary
    cd01241
    Location:5 → 112
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:120 → 473
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133192.1 Reference GRCz12tu Primary Assembly

    Range
    2574325..2674616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467101.3 → XP_021322776.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    M4MD44
    Conserved Domains (2) summary
    cd01241
    Location:5 → 112
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:120 → 473
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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