Unc45a unc-45 myosin chaperone A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc45aprovided by MGI
Official Full Name: unc-45 myosin chaperone Aprovided by MGI
Primary source: MGI:MGI:2142246
See related: Ensembl:ENSMUSG00000030533 AllianceGenome:MGI:2142246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and retina. Orthologous to human UNC45A (unc-45 myosin chaperone A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 26.2), colon adult (RPKM 23.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 D2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79975040..79990748, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80325292..80341000, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
Title: UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
Title: The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW538196 (e-PCR)
- UniSTS:179592

RH140628 (e-PCR)
- UniSTS:222697

Homology

Homologs of the Unc45a gene: The Unc45a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 324 organisms have orthologs with human gene Unc45a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein unc-45 homolog A

Names: SMAP-1; UNC-45A; smooth muscle cell associated protein-1; stromal membrane-associated protein 1; unc-45 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133952.2 → NP_598713.2 protein unc-45 homolog A

See identical proteins and their annotated locations for NP_598713.2

Status: VALIDATED

Source sequence(s)

AK166809, BB842393, CJ323134

Consensus CDS

CCDS21395.1

UniProtKB/Swiss-Prot

Q8C157, Q99KD5

Related

ENSMUSP00000032748.9, ENSMUST00000032748.15

Conserved Domains (3) summary

TIGR00990
Location:7 → 115

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:21 → 49

TPR; TPR repeat [structural motif]

pfam11701
Location:361 → 505

UNC45-central; Myosin-binding striated muscle assembly central

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

79975040..79990748 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250775.1 → XP_011249077.1 protein unc-45 homolog A isoform X2

Related

ENSMUSP00000102991.3, ENSMUST00000107368.9

Conserved Domains (3) summary

TIGR00990
Location:6 → 100

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:6 → 34

TPR; TPR repeat [structural motif]

pfam11701
Location:346 → 490

UNC45-central; Myosin-binding striated muscle assembly central
XM_006540542.2 → XP_006540605.1 protein unc-45 homolog A isoform X3

Conserved Domains (1) summary

pfam11701
Location:216 → 360

UNC45-central; Myosin-binding striated muscle assembly central
XM_011250774.1 → XP_011249076.1 protein unc-45 homolog A isoform X1

See identical proteins and their annotated locations for XP_011249076.1

UniProtKB/Swiss-Prot

Q8C157, Q99KD5

Conserved Domains (3) summary

TIGR00990
Location:7 → 115

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:21 → 49

TPR; TPR repeat [structural motif]

pfam11701
Location:361 → 505

UNC45-central; Myosin-binding striated muscle assembly central
XM_017321917.1 → XP_017177406.1 protein unc-45 homolog A isoform X3

Conserved Domains (1) summary

pfam11701
Location:216 → 360

UNC45-central; Myosin-binding striated muscle assembly central