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Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ Mesocricetus auratus (golden hamster) ]

Gene ID: 101843763, updated on 18-Sep-2024

Summary

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Gene symbol
Cad
Gene description
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
See related
EnsemblRapid:ENSMAUG00000003111
Gene type
protein coding
RefSeq status
MODEL
Organism
Mesocricetus auratus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
Orthologs
human mouse all
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Genomic context

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See Cad in Genome Data Viewer
Location:
chromosome: Un
Exon count:
45
Annotation release Status Assembly Chr Location
103 current BCM_Maur_2.0 (GCF_017639785.1) Unplaced Scaffold NW_024429205.1 (20345275..20367910)
102 previous assembly MesAur1.0 (GCF_000349665.1) Unplaced Scaffold NW_004801644.1 (5903073..5925954)

NW_024429205.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110341515 Neighboring gene solute carrier family 5 member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene solute carrier family 30 member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the junction between the glutamine amidotransferase and carbamyl phosphate synthetase domains of the mammalian CAD protein. Maley JA, et al. Biochem Biophys Res Commun, 1988 Aug 15. PMID 2900634
  2. Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase. Shigesada K, et al. Mol Cell Biol, 1985 Jul. PMID 2862577, Free PMC Article
  3. Mammalian aspartate transcarbamylase (ATCase): sequence of the ATCase domain and interdomain linker in the CAD multifunctional polypeptide and properties of the isolated domain. Simmer JP, et al. Proc Natl Acad Sci U S A, 1989 Jun. PMID 2543974, Free PMC Article
  4. Comparative modeling of mammalian aspartate transcarbamylase. Scully JL, et al. Proteins, 1991. PMID 2006137
  5. Characterization of the 5' end of the growth-regulated Syrian hamster CAD gene. Farnham PJ, et al. Cell Growth Differ, 1990 Apr. PMID 1982061

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aspartate carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of carbamoyl-phosphate synthase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CAD protein
Names
CAD protein carbamylphosphate synthetase domain
dihydrorotate synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mesocricetus auratus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Maur_2.0 Primary Assembly

Genomic

  1. NW_024429205.1 Reference BCM_Maur_2.0 Primary Assembly

    Range
    20345275..20367910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013115966.3 → XP_012971420.2  CAD protein isoform X2

    UniProtKB/TrEMBL
    A0A1U8BZ56
    Related
    ENSMAUP00000003173.2, ENSMAUT00000004234.2
    Conserved Domains (5) summary
    TIGR01645
    Location:70 → 174
    half-pint; poly-U binding splicing factor, half-pint family
    PRK00856
    Location:2090 → 2394
    pyrB; aspartate carbamoyltransferase catalytic subunit
    PRK12564
    Location:153 → 508
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1613 → 1959
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:544 → 1593
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  2. XM_005073537.4 → XP_005073594.3  CAD protein isoform X1

    UniProtKB/TrEMBL
    A0A1U7QS73
    Related
    ENSMAUP00000003134.2, ENSMAUT00000004161.2
    Conserved Domains (5) summary
    TIGR01645
    Location:70 → 174
    half-pint; poly-U binding splicing factor, half-pint family
    PRK00856
    Location:2073 → 2377
    pyrB; aspartate carbamoyltransferase catalytic subunit
    PRK12564
    Location:153 → 508
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1613 → 1959
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:544 → 1593
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08955.4 GenPept UniProtKB/Swiss-Prot:P08955

Gene LinkOut

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