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RBM5 RNA binding motif protein 5 [ Homo sapiens (human) ]

Gene ID: 10181, updated on 7-Sep-2023

Summary

Official Symbol
RBM5provided by HGNC
Official Full Name
RNA binding motif protein 5provided by HGNC
Primary source
HGNC:HGNC:9902
See related
Ensembl:ENSG00000003756 MIM:606884; AllianceGenome:HGNC:9902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G15; H37; RMB5; LUCA15; LUCA-15
Summary
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in skin (RPKM 32.9), endometrium (RPKM 30.9) and 25 other tissues See more
Orthologs
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Genomic context

See RBM5 in Genome Data Viewer
Location:
3p21.31
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50088919..50119021)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50118235..50148343)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50126352..50156454)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49949147-49949724 Neighboring gene MON1 homolog A, secretory trafficking associated Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49977213-49977735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49977736-49978257 Neighboring gene RNA binding motif protein 6 Neighboring gene NANOG hESC enhancer GRCh37_chr3:50050258-50050926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50119658-50120158 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:50120996-50121560 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50126209-50126800 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50126801-50127391 Neighboring gene RBM5 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50157731-50158609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50158610-50159487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50160473-50160973 Neighboring gene SEMA3F antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50162997-50163986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50170449-50170950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50172709-50173300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50177671-50178232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50178233-50178794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50188081-50188752 Neighboring gene basic proline-rich protein-like Neighboring gene Sharpr-MPRA regulatory region 10077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50207797-50208770 Neighboring gene semaphorin 3F Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50230799-50231315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50231316-50231832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50231833-50232348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50232401-50232932 Neighboring gene G protein subunit alpha transducin 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RNA binding motif protein 5 (RBM5) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39876

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 5
Names
putative tumor suppressor LUCA15
renal carcinoma antigen NY-REN-9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030403.1 RefSeqGene

    Range
    5012..35114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005778.4NP_005769.1  RNA-binding protein 5

    See identical proteins and their annotated locations for NP_005769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is protein coding.
    Source sequence(s)
    AC104450, AF091263, BM985111, CN293007, DA776815, DB080737
    Consensus CDS
    CCDS2810.1
    UniProtKB/Swiss-Prot
    B2RA45, B4DM16, B4DMF9, B4DZ63, P52756, Q93021, Q9BU14, Q9HDA6, Q9UKY8, Q9UL24
    UniProtKB/TrEMBL
    A0A024R2U6
    Related
    ENSP00000343054.3, ENST00000347869.8
    Conserved Domains (7) summary
    COG0724
    Location:40181
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:181210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743787
    G-patch; G-patch domain
    cd16168
    Location:455510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

RNA

  1. NR_036627.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104450, AK297249, AU129811, BM985111, BX441555, DB080737, DR762951

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    50088919..50119021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533262.3XP_011531564.1  RNA-binding protein 5 isoform X3

    Conserved Domains (7) summary
    COG0724
    Location:40181
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:181210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:669713
    G-patch; G-patch domain
    cd16168
    Location:455510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
  2. XM_006712917.3XP_006712980.1  RNA-binding protein 5 isoform X1

    Conserved Domains (8) summary
    COG0724
    Location:40181
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:181210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:684728
    G-patch; G-patch domain
    cd16074
    Location:425431
    OCRE; OCRE repeat 4 [structural motif]
    cl23757
    Location:423451
    OCRE; OCRE domain
  3. XM_047447138.1XP_047303094.1  RNA-binding protein 5 isoform X4

  4. XM_011533261.3XP_011531563.1  RNA-binding protein 5 isoform X2

    Conserved Domains (4) summary
    COG0724
    Location:40181
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    pfam01585
    Location:669713
    G-patch; G-patch domain
    cd16168
    Location:381436
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
  5. XM_017005504.3XP_016860993.1  RNA-binding protein 5 isoform X5

    Conserved Domains (4) summary
    smart00443
    Location:608654
    G_patch; glycine rich nucleic binding domain
    smart00360
    Location:99171
    RRM; RNA recognition motif
    cd16074
    Location:351357
    OCRE; OCRE repeat 4 [structural motif]
    cl23757
    Location:349377
    OCRE; OCRE domain
  6. XM_047447140.1XP_047303096.1  RNA-binding protein 5 isoform X7

  7. XM_047447139.1XP_047303095.1  RNA-binding protein 5 isoform X6

    UniProtKB/TrEMBL
    Q59HE6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    50118235..50148343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344846.1XP_054200821.1  RNA-binding protein 5 isoform X3

  2. XM_054344844.1XP_054200819.1  RNA-binding protein 5 isoform X1

  3. XM_054344847.1XP_054200822.1  RNA-binding protein 5 isoform X4

  4. XM_054344845.1XP_054200820.1  RNA-binding protein 5 isoform X2

  5. XM_054344848.1XP_054200823.1  RNA-binding protein 5 isoform X5

  6. XM_054344850.1XP_054200825.1  RNA-binding protein 5 isoform X7

  7. XM_054344849.1XP_054200824.1  RNA-binding protein 5 isoform X6

    UniProtKB/TrEMBL
    Q59HE6