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CASC9 cancer susceptibility 9 [ Homo sapiens (human) ]

Gene ID: 101805492, updated on 3-Mar-2026
Official Symbol
CASC9provided by HGNC
Official Full Name
cancer susceptibility 9provided by HGNC
Primary source
HGNC:HGNC:48906
See related
Ensembl:ENSG00000249395 AllianceGenome:HGNC:48906
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESSCAL1; ESCCAL-1; LINC00981; linc-JPH1
Expression
Biased expression in colon (RPKM 1.7), placenta (RPKM 0.9) and 8 other tissues See more
Try the new Gene page
Try the new Transcripts and proteins table
See CASC9 in Genome Data Viewer
Location:
8q21.13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (75223117..75278889, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (75652630..75708379, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (76135352..76191124, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cysteine rich secretory protein LCCL domain containing 1 Neighboring gene uncharacterized LOC124901964 Neighboring gene uncharacterized LOC105375905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:76042510-76043087 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:76131164-76131759 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:76190151-76191350 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 6 Neighboring gene pyruvate kinase M1/2 pseudogene 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein. Liang Y, et al. Cell Death Differ, 2018 Nov. PMID 29511340, Free PMC Article
  2. The expression, significance and function of cancer susceptibility candidate 9 in lung squamous cell carcinoma: A bioinformatics and in vitro investigation. Gao L, et al. Int J Oncol, 2019 May. PMID 30896821, Free PMC Article
  3. Upregulation of the long non-coding RNA CASC9 as a biomarker for squamous cell carcinoma. Sassenberg M, et al. BMC Cancer, 2019 Aug 14. PMID 31412811, Free PMC Article
  4. Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma. Yang Y, et al. Cell Death Dis, 2019 Jan 17. PMID 30674868, Free PMC Article
  5. GLUT-1 participates in the promotion of LncRNA CASC9 in proliferation and metastasis of laryngeal carcinoma cells. Xi J, et al. Gene, 2020 Feb 5. PMID 31669650

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-kappaB signaling pathway.
    Title: CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway.
  2. LncRNA CASC9 promotes cell proliferation and invasion in osteosarcoma through targeting miR-874-3p/SOX12 axis.
    Title: LncRNA CASC9 promotes cell proliferation and invasion in osteosarcoma through targeting miR-874-3p/SOX12 axis.
  3. LncRNA CASC9 activated by STAT3 promotes the invasion of breast cancer and the formation of lymphatic vessels by enhancing H3K27ac-activated SOX4.
    Title: LncRNA CASC9 activated by STAT3 promotes the invasion of breast cancer and the formation of lymphatic vessels by enhancing H3K27ac-activated SOX4.
  4. Abnormal expression of lncRNA CASC9 in pneumonia children with respiratory failure and its feasible value for the clinical diagnosis of patients.
    Title: Abnormal expression of lncRNA CASC9 in pneumonia children with respiratory failure and its feasible value for the clinical diagnosis of patients.
  5. Silencing LncRNA CASC9 inhibits proliferation and invasion of colorectal cancer cells by MiR-542-3p/ILK.
    Title: Silencing LncRNA CASC9 inhibits proliferation and invasion of colorectal cancer cells by MiR-542-3p/ILK.
  6. Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2.
    Title: Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2.
  7. CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY.
    Title: CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY.
  8. Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-kappaB axis promotes proliferation and migration in breast cancer.
    Title: Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer.
  9. LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling.
    Title: LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling.
  10. Long non-coding RNA CASC9 promotes the progression and development of gastric cancer via regulating miR-370/EGFR axis.
    Title: Long non-coding RNA CASC9 promotes the progression and development of gastric cancer via regulating miR-370/EGFR axis.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Other Names

  • ESCC-associated lncRNA
  • cancer susceptibility 9 (non-protein coding)
  • cancer susceptibility candidate 9 (non-protein coding)
  • esophageal squamous cell carcinoma associated lncRNA-1
  • esophageal squamous cell carcinoma sssociated lncRNA-1
  • long intergenic non-protein coding RNA 981

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_103848.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AI205540, BC062758, CN273839
    Related
    ENST00000504531.3

  2. NR_103849.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons and contains an alternate 5' exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC022274

  3. NR_103850.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC022274
    Related
    ENST00000670695.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    75223117..75278889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    75652630..75708379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials