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Ano1 anoctamin 1, calcium activated chloride channel [ Mus musculus (house mouse) ]

Gene ID: 101772, updated on 12-Apr-2024

Summary

Official Symbol
Ano1provided by MGI
Official Full Name
anoctamin 1, calcium activated chloride channelprovided by MGI
Primary source
MGI:MGI:2142149
See related
Ensembl:ENSMUSG00000031075 AllianceGenome:MGI:2142149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem16a
Summary
Enables intracellular calcium activated chloride channel activity; protein homodimerization activity; and voltage-gated chloride channel activity. Involved in several processes, including chloride transmembrane transport; detection of temperature stimulus involved in sensory perception of pain; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within regulation of membrane potential. Located in apical plasma membrane and external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 33.8), genital fat pad adult (RPKM 27.4) and 19 other tissues See more
Orthologs
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Genomic context

See Ano1 in Genome Data Viewer
Location:
7 F5; 7 88.85 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144142286..144305762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144588549..144752026, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E9306 Neighboring gene predicted gene, 35626 Neighboring gene Fas associated via death domain Neighboring gene RIKEN cDNA D930030F02 gene Neighboring gene predicted gene, 34964 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables iodide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of temperature stimulus involved in sensory perception of pain IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glial cell projection elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in iodide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mucus secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trachea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IC
Inferred by Curator
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
anoctamin-1
Names
transmembrane protein 16A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242349.2NP_001229278.2  anoctamin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122336, AC153792
    Consensus CDS
    CCDS57600.1
    UniProtKB/TrEMBL
    A0A348BSL7
    Related
    ENSMUSP00000113899.4, ENSMUST00000118556.9
    Conserved Domains (2) summary
    pfam04547
    Location:320896
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:54317
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  2. NM_001420255.1NP_001407184.1  anoctamin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122336, AC153792
  3. NM_178642.6NP_848757.5  anoctamin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122336, AC153792
    Consensus CDS
    CCDS40202.2
    UniProtKB/Swiss-Prot
    Q6P5C6, Q8BHY3, Q8BI26, Q99JK1
    UniProtKB/TrEMBL
    A0A348BSL7
    Related
    ENSMUSP00000112616.4, ENSMUST00000121758.8
    Conserved Domains (2) summary
    pfam04547
    Location:320900
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:54317
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144142286..144305762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508463.5XP_006508526.1  anoctamin-1 isoform X8

    UniProtKB/TrEMBL
    A0A348BSL7
    Conserved Domains (2) summary
    pfam04547
    Location:366972
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:78363
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  2. XM_006508459.5XP_006508522.1  anoctamin-1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MQF2
    Conserved Domains (2) summary
    pfam04547
    Location:3991005
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:111396
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  3. XM_006508458.5XP_006508521.1  anoctamin-1 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MQF2
    Conserved Domains (2) summary
    pfam04547
    Location:4001006
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:112397
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  4. XM_030241958.2XP_030097818.1  anoctamin-1 isoform X6

    UniProtKB/TrEMBL
    A0A0A0MQF2
    Conserved Domains (2) summary
    pfam04547
    Location:377983
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:111374
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  5. XM_030241960.2XP_030097820.1  anoctamin-1 isoform X7

    UniProtKB/TrEMBL
    G8JL82
    Conserved Domains (2) summary
    pfam04547
    Location:399975
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:111396
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  6. XM_030241957.2XP_030097817.1  anoctamin-1 isoform X5

    UniProtKB/TrEMBL
    A0A0A0MQF2
    Conserved Domains (2) summary
    pfam04547
    Location:378984
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:112375
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  7. XM_017321913.3XP_017177402.1  anoctamin-1 isoform X12

    UniProtKB/TrEMBL
    A0A0A0MQF2
    Conserved Domains (2) summary
    pfam04547
    Location:400980
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:112397
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  8. XM_006508464.4XP_006508527.1  anoctamin-1 isoform X10

    UniProtKB/TrEMBL
    A0A348BSL7
    Conserved Domains (2) summary
    pfam04547
    Location:342948
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:54339
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  9. XM_011241973.4XP_011240275.3  anoctamin-1 isoform X1

    UniProtKB/TrEMBL
    A0A348BSL7
    Conserved Domains (2) summary
    pfam04547
    Location:342944
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:54339
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  10. XM_030241955.2XP_030097815.2  anoctamin-1 isoform X3

    UniProtKB/TrEMBL
    A0A348BSL7, A0A5F8MPM2
    Related
    ENSMUSP00000159034.3, ENSMUST00000238848.2
    Conserved Domains (2) summary
    pfam04547
    Location:320922
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:54317
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
  11. XM_011241976.3XP_011240278.1  anoctamin-1 isoform X11

    Conserved Domains (1) summary
    pfam04547
    Location:1586
    Anoctamin; Calcium-activated chloride channel