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Sh2b2 SH2B adaptor protein 2 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101724022, updated on 1-Mar-2025
Gene symbol
Sh2b2
Gene description
SH2B adaptor protein 2
See related
Ensembl:ENSHGLG00000015375 RGD:18936305
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Location:
chromosome: Un
Exon count:
10
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624740.1 (15266759..15289420, complement)

NW_004624740.1Genomic Context describing neighboring genes Neighboring gene PRKR interacting protein 1 Neighboring gene ubiquitin-conjugating enzyme E2 C pseudogene Neighboring gene cut like homeobox 1 Neighboring gene uncharacterized LOC110348226 Neighboring gene coiled-coil domain-containing protein 181 pseudogene

Genomic Sequence:
NW_004624740 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen receptor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
SH2B adapter protein 2

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624740.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    15266759..15289420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004840120.2 → XP_004840177.1  SH2B adapter protein 2 isoform X3

    UniProtKB/TrEMBL
    A0AAX6NZ16
    Conserved Domains (4) summary
    cd10411
    Location:473 → 568
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:265 → 380
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 374
    PH; PH domain
    pfam08916
    Location:92 → 148
    Phe_ZIP; Phenylalanine zipper

  2. XM_004840119.2 → XP_004840176.1  SH2B adapter protein 2 isoform X2

    UniProtKB/TrEMBL
    A0AAX6NZ34
    Conserved Domains (4) summary
    cd10411
    Location:479 → 574
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:265 → 380
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 374
    PH; PH domain
    pfam08916
    Location:92 → 148
    Phe_ZIP; Phenylalanine zipper

  3. XM_004840118.2 → XP_004840175.1  SH2B adapter protein 2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6NZ96
    Conserved Domains (4) summary
    cd10411
    Location:480 → 575
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:265 → 380
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 374
    PH; PH domain
    pfam08916
    Location:92 → 148
    Phe_ZIP; Phenylalanine zipper

  4. XM_004840121.2 → XP_004840178.1  SH2B adapter protein 2 isoform X4

    UniProtKB/TrEMBL
    A0AAX6NZ23, G5AXB0
    Related
    ENSHGLP00000021520.1, ENSHGLT00000021729.1
    Conserved Domains (4) summary
    cd10411
    Location:399 → 494
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:184 → 299
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:202 → 293
    PH; PH domain
    pfam08916
    Location:11 → 67
    Phe_ZIP; Phenylalanine zipper
Nucleotide Protein
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