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Dicer1 dicer 1, ribonuclease III [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101721048, updated on 8-Mar-2024

Summary

Gene symbol
Dicer1
Gene description
dicer 1, ribonuclease III
Locus tag
GW7_16181
See related
Ensembl:ENSHGLG00000018124
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
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Genomic context

See Dicer1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
28
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624734.1 (7604049..7681481, complement)

NW_004624734.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110346766 Neighboring gene uncharacterized LOC110346769 Neighboring gene goosecoid homeobox Neighboring gene calmin Neighboring gene uncharacterized LOC110345851

Genomic regions, transcripts, and products

Genomic Sequence:
NW_004624734 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables deoxyribonuclease I activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in siRNA processing IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
endoribonuclease Dicer
Names
Endoribonuclease Dicer

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624734.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    7604049..7681481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004837007.3XP_004837064.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_004837064.1

    UniProtKB/TrEMBL
    G5B488
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16791931
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  2. XM_004837008.3XP_004837065.1  endoribonuclease Dicer isoform X1

    See identical proteins and their annotated locations for XP_004837065.1

    UniProtKB/TrEMBL
    G5B488
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16791931
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  3. XM_021244658.1XP_021100317.1  endoribonuclease Dicer isoform X1

    UniProtKB/TrEMBL
    G5B488
    Related
    ENSHGLP00000025442.1, ENSHGLT00000025667.1
    Conserved Domains (5) summary
    smart00535
    Location:12961387
    RIBOc; Ribonuclease III family
    COG0571
    Location:16791931
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630718
    Dicer_dimer; Dicer dimerisation domain
    cl17041
    Location:37553
    helicase_insert_domain; helicase_insert_domain
  4. XM_021244665.1XP_021100324.1  endoribonuclease Dicer isoform X2

    Conserved Domains (5) summary
    smart00535
    Location:803894
    RIBOc; Ribonuclease III family
    COG0571
    Location:11861438
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd02843
    Location:393515
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam00271
    Location:860
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:137225
    Dicer_dimer; Dicer dimerisation domain