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Mertk MER proto-oncogene, tyrosine kinase [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101718876, updated on 1-Mar-2025
Gene symbol
Mertk
Gene description
MER proto-oncogene, tyrosine kinase
Locus tag
GW7_17937
See related
Ensembl:ENSHGLG00000005187 RGD:18905527
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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See Mertk in Genome Data Viewer
Location:
chromosome: Un
Exon count:
25
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624749.1 (337441..444730, complement)

NW_004624749.1Genomic Context describing neighboring genes Neighboring gene fibulin 7 Neighboring gene transmembrane protein 87B Neighboring gene DCN1-like protein 1 pseudogene Neighboring gene protein FAM204A pseudogene Neighboring gene integrator complex subunit 10 pseudogene Neighboring gene anaphase promoting complex subunit 1

Genomic Sequence:
NW_004624749 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase Mer
Names
Proto-oncogene tyrosine-protein kinase MER
c-mer proto-oncogene tyrosine kinase

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624749.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    337441..444730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021257967.1 → XP_021113626.1  tyrosine-protein kinase Mer isoform X2

    UniProtKB/TrEMBL
    A0AAX6SV36
    Conserved Domains (5) summary
    cd05749
    Location:257 → 337
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:342 → 436
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:636 → 919
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:162 → 239
    ig; Immunoglobulin domain
    cl26464
    Location:2 → 150
    Atrophin-1; Atrophin-1 family

  2. XM_021257966.1 → XP_021113625.1  tyrosine-protein kinase Mer isoform X1

    UniProtKB/TrEMBL
    A0AAX6SWQ6
    Conserved Domains (5) summary
    cd05749
    Location:257 → 337
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:342 → 436
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:636 → 919
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:162 → 239
    ig; Immunoglobulin domain
    cl26464
    Location:2 → 150
    Atrophin-1; Atrophin-1 family

  3. XM_004844311.2 → XP_004844368.1  tyrosine-protein kinase Mer isoform X3

    UniProtKB/TrEMBL
    A0A0P6J3I5
    Related
    ENSHGLP00000007105.1, ENSHGLT00000007190.1
    Conserved Domains (6) summary
    cd00096
    Location:106 → 185
    Ig; Immunoglobulin domain
    cd05749
    Location:195 → 275
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00410
    Location:199 → 276
    IG_like; Immunoglobulin like
    cd00063
    Location:280 → 374
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:574 → 857
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam07714
    Location:582 → 849
    Pkinase_Tyr; Protein tyrosine kinase

  4. XM_004844312.2 → XP_004844369.1  tyrosine-protein kinase Mer isoform X5

    UniProtKB/TrEMBL
    A0AAX6P5K8
    Conserved Domains (6) summary
    cd00096
    Location:93 → 172
    Ig; Immunoglobulin domain
    cd05749
    Location:182 → 262
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00410
    Location:186 → 263
    IG_like; Immunoglobulin like
    cd00063
    Location:267 → 361
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:561 → 844
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam07714
    Location:569 → 836
    Pkinase_Tyr; Protein tyrosine kinase

  5. XM_021257968.1 → XP_021113627.1  tyrosine-protein kinase Mer isoform X4

    UniProtKB/TrEMBL
    G5BQY7
    Conserved Domains (4) summary
    cd05749
    Location:171 → 251
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:256 → 350
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:550 → 833
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:76 → 153
    ig; Immunoglobulin domain

  6. XM_004844314.3 → XP_004844371.1  tyrosine-protein kinase Mer isoform X4

    See identical proteins and their annotated locations for XP_004844371.1

    UniProtKB/TrEMBL
    G5BQY7
    Conserved Domains (4) summary
    cd05749
    Location:171 → 251
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:256 → 350
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:550 → 833
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:76 → 153
    ig; Immunoglobulin domain

  7. XM_004844315.3 → XP_004844372.1  tyrosine-protein kinase Mer isoform X4

    See identical proteins and their annotated locations for XP_004844372.1

    UniProtKB/TrEMBL
    G5BQY7
    Conserved Domains (4) summary
    cd05749
    Location:171 → 251
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:256 → 350
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:550 → 833
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:76 → 153
    ig; Immunoglobulin domain
Nucleotide Protein
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