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Traf3 TNF receptor associated factor 3 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101718736, updated on 1-Mar-2025
Gene symbol
Traf3
Gene description
TNF receptor associated factor 3
See related
Ensembl:ENSHGLG00000015639 RGD:18928168
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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See Traf3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
13
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624734.1 (1728353..1820345, complement)

NW_004624734.1Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein Neighboring gene zinc finger MYM-type protein 5-like Neighboring gene REST corepressor 1 Neighboring gene tRNA (uracil-5-)-methyltransferase homolog A pseudogene Neighboring gene ankyrin repeat domain 9

Genomic Sequence:
NW_004624734 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of plasma membrane signaling receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
TNF receptor-associated factor 3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624734.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    1728353..1820345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013066392.2 → XP_012921846.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_012921846.1

    UniProtKB/TrEMBL
    A0AAX6QNL1
    Conserved Domains (4) summary
    cd03777
    Location:380 → 565
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:259 → 388
    mycoplas_twoTM; two transmembrane protein
    pfam00097
    Location:55 → 90
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger

  2. XM_013066397.2 → XP_012921851.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0AAX6QLZ6
    Conserved Domains (4) summary
    cd03777
    Location:355 → 540
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:234 → 363
    mycoplas_twoTM; two transmembrane protein
    pfam00097
    Location:55 → 90
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger

  3. XM_013066387.2 → XP_012921841.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_012921841.1

    UniProtKB/TrEMBL
    A0AAX6QNL1
    Conserved Domains (4) summary
    cd03777
    Location:380 → 565
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:259 → 388
    mycoplas_twoTM; two transmembrane protein
    pfam00097
    Location:55 → 90
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger

  4. XM_004836913.3 → XP_004836970.1  TNF receptor-associated factor 3 isoform X4

    UniProtKB/TrEMBL
    A0AAX6NU83
    Related
    ENSHGLP00000021917.1, ENSHGLT00000022127.1
    Conserved Domains (5) summary
    cd03777
    Location:352 → 537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:55 → 90
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    pfam15272
    Location:237 → 295
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17082
    Location:281 → 340
    Spc29; Spindle Pole Component 29

  5. XM_004836910.3 → XP_004836967.1  TNF receptor-associated factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A0N8ET26
    Related
    ENSHGLP00000021916.1, ENSHGLT00000022126.1
    Conserved Domains (5) summary
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:55 → 90
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    pfam15272
    Location:266 → 320
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17082
    Location:306 → 365
    Spc29; Spindle Pole Component 29

  6. XM_013066388.2 → XP_012921842.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_012921842.1

    UniProtKB/TrEMBL
    A0AAX6QNL1
    Conserved Domains (4) summary
    cd03777
    Location:380 → 565
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:259 → 388
    mycoplas_twoTM; two transmembrane protein
    pfam00097
    Location:55 → 90
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
Nucleotide Protein
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