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Dtx2 deltex E3 ubiquitin ligase 2 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101717817, updated on 1-Mar-2025
Gene symbol
Dtx2
Gene description
deltex E3 ubiquitin ligase 2
Locus tag
GW7_12436
See related
Ensembl:ENSHGLG00000016235 RGD:18910583
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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See Dtx2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624740.1 (15055984..15098322)

NW_004624740.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene zona pellucida glycoprotein 3 Neighboring gene cell division control protein 42 homolog pseudogene Neighboring gene uroplakin 3B Neighboring gene uroplakin 3B like 2

Genomic Sequence:
NW_004624740 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
probable E3 ubiquitin-protein ligase DTX2
Names
Protein deltex-2
deltex homolog 2
putative E3 ubiquitin-protein ligase DTX2

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624740.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    15055984..15098322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004840106.2 → XP_004840163.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_004840163.1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Related
    ENSHGLP00000022764.1, ENSHGLT00000022978.1
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  2. XM_021254440.1 → XP_021110099.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  3. XM_021254442.1 → XP_021110101.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  4. XM_021254441.1 → XP_021110100.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  5. XM_021254443.1 → XP_021110102.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  6. XM_004840100.3 → XP_004840157.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_004840157.1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Related
    ENSHGLP00000022765.1, ENSHGLT00000022979.1
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  7. XM_004840105.3 → XP_004840162.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_004840162.1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  8. XM_021254444.1 → XP_021110103.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6NZB7, G5AXA0
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:478 → 610
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:204 → 407
    Atrophin-1; Atrophin-1 family

  9. XM_021254445.1 → XP_021110104.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    A0AAX6SMM0, G5AXA0
    Related
    ENSHGLP00000022766.1, ENSHGLT00000022980.1
    Conserved Domains (3) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:431 → 563
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:361 → 432
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
Nucleotide Protein
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