U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vps4a vacuolar protein sorting 4 homolog A [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101716007, updated on 1-Mar-2025
Gene symbol
Vps4a
Gene description
vacuolar protein sorting 4 homolog A
See related
Ensembl:ENSHGLG00000016678 RGD:18914810
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Vps4a in Genome Data Viewer
Location:
chromosome: Un
Exon count:
13
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (17044173..17059295, complement)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene nucleolar pre-rRNA processing protein NIP7 Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene component of oligomeric golgi complex 8 Neighboring gene peptide deformylase, mitochondrial Neighboring gene syntrophin beta 2 Neighboring gene UTP4 small subunit processome component

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vacuole organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
vacuolar protein sorting-associated protein 4A

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    17044173..17059295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013071524.2 → XP_012926978.1  vacuolar protein sorting-associated protein 4A isoform X4

    UniProtKB/TrEMBL
    A0AAX6QXE6, G5AK48
    Conserved Domains (5) summary
    smart00382
    Location:159 → 295
    AAA; ATPases associated with a variety of cellular activities
    cd02678
    Location:4 → 79
    MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
    pfam00004
    Location:163 → 293
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:374 → 404
    Vps4_C; Vps4 C terminal oligomerization domain
    cl21455
    Location:128 → 182
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_021256782.1 → XP_021112441.1  vacuolar protein sorting-associated protein 4A isoform X1

    UniProtKB/TrEMBL
    A0AAX6QWM2, G5AK48
    Conserved Domains (2) summary
    COG0464
    Location:26 → 348
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:374 → 434
    Vps4_C; Vps4 C terminal oligomerization domain

  3. XM_021256780.1 → XP_021112439.1  vacuolar protein sorting-associated protein 4A isoform X1

    UniProtKB/TrEMBL
    A0AAX6QWM2, G5AK48
    Conserved Domains (2) summary
    COG0464
    Location:26 → 348
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:374 → 434
    Vps4_C; Vps4 C terminal oligomerization domain

  4. XM_021256781.1 → XP_021112440.1  vacuolar protein sorting-associated protein 4A isoform X1

    UniProtKB/TrEMBL
    A0AAX6QWM2, G5AK48
    Conserved Domains (2) summary
    COG0464
    Location:26 → 348
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:374 → 434
    Vps4_C; Vps4 C terminal oligomerization domain

  5. XM_013071521.2 → XP_012926975.1  vacuolar protein sorting-associated protein 4A isoform X1

    See identical proteins and their annotated locations for XP_012926975.1

    UniProtKB/TrEMBL
    A0AAX6QWM2, G5AK48
    Conserved Domains (2) summary
    COG0464
    Location:26 → 348
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:374 → 434
    Vps4_C; Vps4 C terminal oligomerization domain

  6. XM_013071522.2 → XP_012926976.1  vacuolar protein sorting-associated protein 4A isoform X2

    UniProtKB/TrEMBL
    A0A0P6JTN1, G5AK48
    Conserved Domains (5) summary
    smart00382
    Location:158 → 294
    AAA; ATPases associated with a variety of cellular activities
    cd02678
    Location:4 → 79
    MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
    pfam00004
    Location:162 → 292
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:373 → 433
    Vps4_C; Vps4 C terminal oligomerization domain
    cl21455
    Location:127 → 181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. XM_004842955.2 → XP_004843012.1  vacuolar protein sorting-associated protein 4A isoform X1

    See identical proteins and their annotated locations for XP_004843012.1

    UniProtKB/TrEMBL
    A0AAX6QWM2, G5AK48
    Conserved Domains (2) summary
    COG0464
    Location:26 → 348
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:374 → 434
    Vps4_C; Vps4 C terminal oligomerization domain

  8. XM_021256783.1 → XP_021112442.1  vacuolar protein sorting-associated protein 4A isoform X3

    UniProtKB/TrEMBL
    A0AAX6STQ4, G5AK48
    Related
    ENSHGLP00000023398.1, ENSHGLT00000023615.1
    Conserved Domains (2) summary
    COG0464
    Location:20 → 342
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:368 → 428
    Vps4_C; Vps4 C terminal oligomerization domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases