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Nfat5 nuclear factor of activated T cells 5 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101711867, updated on 1-Mar-2025
Gene symbol
Nfat5
Gene description
nuclear factor of activated T cells 5
Locus tag
GW7_20935
See related
Ensembl:ENSHGLG00000014649 RGD:18910636
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Location:
chromosome: Un
Exon count:
18
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (16684556..16818321, complement)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene cytochrome b5 type B Neighboring gene translation machinery-associated protein 16 pseudogene

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
nuclear factor of activated T-cells 5
Names
nuclear factor of activated T-cells 5, tonicity-responsive

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    16684556..16818321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021256776.1 → XP_021112435.1  nuclear factor of activated T-cells 5 isoform X1

    UniProtKB/TrEMBL
    G5AK40
    Related
    ENSHGLP00000020492.1, ENSHGLT00000020694.1
    Conserved Domains (3) summary
    cd07882
    Location:298 → 458
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:462 → 561
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl25764
    Location:1187 → 1340
    PAT1; Topoisomerase II-associated protein PAT1

  2. XM_004842938.3 → XP_004842995.1  nuclear factor of activated T-cells 5 isoform X2

    UniProtKB/TrEMBL
    A0AAX6P3B1
    Related
    ENSHGLP00000020493.1, ENSHGLT00000020695.1
    Conserved Domains (3) summary
    cd07882
    Location:298 → 458
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:462 → 561
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:1049 → 1513
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. XM_013071520.2 → XP_012926974.1  nuclear factor of activated T-cells 5 isoform X4

    UniProtKB/TrEMBL
    A0AAX6QT87
    Related
    ENSHGLP00000020494.1, ENSHGLT00000020696.1
    Conserved Domains (3) summary
    cd07882
    Location:280 → 440
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:444 → 543
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:1031 → 1495
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  4. XM_004842937.3 → XP_004842994.1  nuclear factor of activated T-cells 5 isoform X1

    See identical proteins and their annotated locations for XP_004842994.1

    UniProtKB/TrEMBL
    G5AK40
    Conserved Domains (3) summary
    cd07882
    Location:298 → 458
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:462 → 561
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl25764
    Location:1187 → 1340
    PAT1; Topoisomerase II-associated protein PAT1

  5. XM_004842939.3 → XP_004842996.1  nuclear factor of activated T-cells 5 isoform X3

    UniProtKB/TrEMBL
    A0AAX6P3Y2
    Conserved Domains (3) summary
    cd07882
    Location:280 → 440
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:444 → 543
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:1032 → 1496
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  6. XM_004842940.3 → XP_004842997.1  nuclear factor of activated T-cells 5 isoform X5

    UniProtKB/TrEMBL
    A0AAX6P3Y1
    Conserved Domains (3) summary
    cd07882
    Location:204 → 364
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:368 → 467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:956 → 1420
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  7. XM_021256777.1 → XP_021112436.1  nuclear factor of activated T-cells 5 isoform X6

    UniProtKB/TrEMBL
    A0AAX6SSU0
    Conserved Domains (3) summary
    cd07882
    Location:13 → 173
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:177 → 276
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl25764
    Location:902 → 1055
    PAT1; Topoisomerase II-associated protein PAT1
Nucleotide Protein
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