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Actn1 actinin alpha 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101711839, updated on 8-Mar-2024

Summary

Gene symbol
Actn1
Gene description
actinin alpha 1
See related
Ensembl:ENSHGLG00000012556
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
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Genomic context

See Actn1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
24
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624734.1 (32097364..32190162)

NW_004624734.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101711222 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene uncharacterized LOC110346403 Neighboring gene uncharacterized LOC110346404 Neighboring gene ZFP36 ring finger protein like 1

Genomic regions, transcripts, and products

Genomic Sequence:
NW_004624734 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624734.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    32097364..32190162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004837338.3XP_004837395.1  alpha-actinin-1 isoform X4

    UniProtKB/TrEMBL
    G5C7W9
    Related
    ENSHGLP00000017551.1, ENSHGLT00000017726.1
    Conserved Domains (7) summary
    cd00014
    Location:145249
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:750812
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:32130
    CH; Calponin homology (CH) domain
    pfam00435
    Location:634733
    Spectrin; Spectrin repeat
    pfam08726
    Location:817883
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:752811
    EF-hand_7; EF-hand domain pair
  2. XM_004837336.3XP_004837393.1  alpha-actinin-1 isoform X1

    UniProtKB/TrEMBL
    G5C7W9
    Related
    ENSHGLP00000017549.1, ENSHGLT00000017724.1
    Conserved Domains (7) summary
    cd00014
    Location:145249
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:750839
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:32130
    CH; Calponin homology (CH) domain
    pfam00435
    Location:634733
    Spectrin; Spectrin repeat
    pfam08726
    Location:844910
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:752838
    EF-hand_7; EF-hand domain pair
  3. XM_004837337.3XP_004837394.1  alpha-actinin-1 isoform X3

    UniProtKB/TrEMBL
    G5C7W9
    Related
    ENSHGLP00000017550.1, ENSHGLT00000017725.1
    Conserved Domains (7) summary
    cd00014
    Location:145249
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:750817
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:32130
    CH; Calponin homology (CH) domain
    pfam00435
    Location:634733
    Spectrin; Spectrin repeat
    pfam08726
    Location:822888
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:752816
    EF-hand_7; EF-hand domain pair
  4. XM_021247345.1XP_021103004.1  alpha-actinin-1 isoform X5

    UniProtKB/TrEMBL
    G5C7W9
    Conserved Domains (5) summary
    COG5069
    Location:3227
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:685774
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:330557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:209319
    Spectrin; Spectrin repeat
    pfam08726
    Location:779845
    EFhand_Ca_insen; Ca2+ insensitive EF hand
  5. XM_021247339.1XP_021102998.1  alpha-actinin-1 isoform X2

    UniProtKB/TrEMBL
    G5C7W9
    Related
    ENSHGLP00000017553.1, ENSHGLT00000017728.1
    Conserved Domains (5) summary
    COG5069
    Location:13272
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:730819
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:375602
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:254364
    Spectrin; Spectrin repeat
    pfam08726
    Location:824890
    EFhand_Ca_insen; Ca2+ insensitive EF hand