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Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101711605, updated on 1-Mar-2025
Gene symbol
Eif2ak1
Gene description
eukaryotic translation initiation factor 2 alpha kinase 1
Locus tag
GW7_17913
See related
Ensembl:ENSHGLG00000015194 RGD:18901359
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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See Eif2ak1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624740.1 (31223583..31306749)

NW_004624740.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 10-like protein 2A Neighboring gene family with sequence similarity 220 member A Neighboring gene cytohesin 3 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene zinc finger protein 280A-like Neighboring gene ankyrin repeat domain 61 Neighboring gene radial spoke head 10 homolog B Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 2 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated

Genomic Sequence:
NW_004624740 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
eukaryotic translation initiation factor 2-alpha kinase 1

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624740.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    31223583..31306749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021254743.1 → XP_021110402.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0N8ESR3, A0AAX6SLG6
    Conserved Domains (1) summary
    cd14049
    Location:60 → 481
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

  2. XM_021254744.1 → XP_021110403.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0N8ESR3, A0AAX6SLG6
    Conserved Domains (1) summary
    cd14049
    Location:60 → 481
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

  3. XM_021254741.1 → XP_021110400.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0N8ESR3, A0AAX6SLG6
    Conserved Domains (1) summary
    cd14049
    Location:60 → 481
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

  4. XM_021254742.1 → XP_021110401.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0N8ESR3, A0AAX6SLG6
    Conserved Domains (1) summary
    cd14049
    Location:60 → 481
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

  5. XM_004840453.2 → XP_004840510.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0N8ESR3, A0AAX6NZY9
    Conserved Domains (2) summary
    cd14049
    Location:160 → 581
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase
    pfam00069
    Location:167 → 583
    Pkinase; Protein kinase domain

  6. XM_021254740.1 → XP_021110399.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A0N8ESR3, A0AAX6SP61
    Related
    ENSHGLP00000021266.1, ENSHGLT00000021472.1
    Conserved Domains (1) summary
    cd14049
    Location:160 → 580
    STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase
Nucleotide Protein
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