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Sptb spectrin beta, erythrocytic [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101704610, updated on 8-Mar-2024

Summary

Gene symbol
Sptb
Gene description
spectrin beta, erythrocytic
See related
Ensembl:ENSHGLG00000016387
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
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Genomic context

See Sptb in Genome Data Viewer
Location:
chromosome: Un
Exon count:
35
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624734.1 (36151701..36272058)

NW_004624734.1Genomic Context describing neighboring genes Neighboring gene cytochrome c-like Neighboring gene churchill domain containing 1 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 pseudogene Neighboring gene protein RUFY3 pseudogene Neighboring gene pleckstrin homology and RhoGEF domain containing G3 Neighboring gene eukaryotic translation initiation factor 2 subunit 3 pseudogene Neighboring gene uncharacterized LOC110346834

Genomic regions, transcripts, and products

Genomic Sequence:
NW_004624734 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
part_of spectrin IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
spectrin beta chain, erythrocytic

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624734.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    36151701..36272058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004837405.3XP_004837462.1  spectrin beta chain, erythrocytic isoform X1

    UniProtKB/TrEMBL
    G5BD06
    Conserved Domains (7) summary
    smart00150
    Location:14211501
    SPEC; Spectrin repeats
    smart00033
    Location:177273
    CH; Calponin homology domain
    cd00014
    Location:55158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:15111716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:22082339
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:22062303
    PH; PH domain
    pfam00435
    Location:422525
    Spectrin; Spectrin repeat
  2. XM_021247699.1XP_021103358.1  spectrin beta chain, erythrocytic isoform X2

    UniProtKB/TrEMBL
    G5BD06
    Related
    ENSHGLP00000022977.1, ENSHGLT00000023191.1
    Conserved Domains (5) summary
    smart00150
    Location:14211501
    SPEC; Spectrin repeats
    COG5069
    Location:48454
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:15111716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:22082313
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00435
    Location:422525
    Spectrin; Spectrin repeat