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Dhodh dihydroorotate dehydrogenase (quinone) [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101704063, updated on 1-Mar-2025
Gene symbol
Dhodh
Gene description
dihydroorotate dehydrogenase (quinone)
See related
Ensembl:ENSHGLG00000012868 RGD:18902352
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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See Dhodh in Genome Data Viewer
Location:
chromosome: Un
Exon count:
10
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (14254811..14268034)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 821 Neighboring gene IST1 homolog Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene thioredoxin like 4B Neighboring gene haptoglobin

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
dihydroorotate dehydrogenase (quinone), mitochondrial

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    14254811..14268034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021256746.1 → XP_021112405.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0AAX6SXD2, G5B5U5
    Conserved Domains (1) summary
    cd04738
    Location:43 → 324
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

  2. XM_004842917.2 → XP_004842974.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0AAX6P3Q3
    Conserved Domains (1) summary
    cd04738
    Location:43 → 319
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

  3. XM_004842916.2 → XP_004842973.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A0N8ETI6, G5B5U5
    Related
    ENSHGLP00000017959.1, ENSHGLT00000018136.1
    Conserved Domains (2) summary
    PLN02826
    Location:38 → 394
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:43 → 373
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

  4. XM_021256747.1 → XP_021112406.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X5

    UniProtKB/TrEMBL
    A0AAX6SSQ7, G5B5U5
    Conserved Domains (1) summary
    cd04738
    Location:8 → 302
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

  5. XM_021256745.1 → XP_021112404.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0AAX6SU96, G5B5U5
    Conserved Domains (1) summary
    cd04738
    Location:9 → 334
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

  6. XM_021256748.1 → XP_021112407.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X6

    UniProtKB/TrEMBL
    A0AAX6SRV4, G5B5U5
    Conserved Domains (1) summary
    cd04738
    Location:2 → 332
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...
Nucleotide Protein
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