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Kars1 lysyl-tRNA synthetase 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101704062, updated on 1-Mar-2025
Gene symbol
Kars1
Gene description
lysyl-tRNA synthetase 1
Locus tag
GW7_15483
See related
Ensembl:ENSHGLG00000011898 RGD:18905521
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Also known as
Kars
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Kars1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
16
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (11337505..11354950)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L pseudogene Neighboring gene TERF2 interacting protein Neighboring gene uncharacterized LOC110348764 Neighboring gene adenosine deaminase tRNA specific 1 Neighboring gene GABA type A receptor associated protein like 2

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lysine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in basophil activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in diadenosine tetraphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lysyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
lysine--tRNA ligase

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    11337505..11354950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004842825.3 → XP_004842882.1  lysine--tRNA ligase isoform X2

    UniProtKB/TrEMBL
    A0AAX6P3P0
    Related
    ENSHGLP00000016633.1, ENSHGLT00000016803.1
    Conserved Domains (4) summary
    PLN02502
    Location:16 → 576
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:236 → 574
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:124 → 233
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
    pfam08496
    Location:16 → 45
    Peptidase_S49_N; Peptidase family S49 N-terminal

  2. XM_004842823.3 → XP_004842880.1  lysine--tRNA ligase isoform X1

    See identical proteins and their annotated locations for XP_004842880.1

    UniProtKB/TrEMBL
    G5B5Y6
    Conserved Domains (3) summary
    PLN02502
    Location:47 → 604
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:264 → 602
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:152 → 261
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

  3. XM_004842824.3 → XP_004842881.1  lysine--tRNA ligase isoform X1

    See identical proteins and their annotated locations for XP_004842881.1

    UniProtKB/TrEMBL
    G5B5Y6
    Related
    ENSHGLP00000016634.1, ENSHGLT00000016804.1
    Conserved Domains (3) summary
    PLN02502
    Location:47 → 604
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:264 → 602
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:152 → 261
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

RNA

  1. XR_002394289.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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